A0A1L4BJ95 · A0A1L4BJ95_HEMLE

Function

function

Converts sphingomyelin to ceramide.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site.

161550100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site210Zn2+ 1 (UniProtKB | ChEBI)
Binding site212Zn2+ 1 (UniProtKB | ChEBI)
Binding site282Zn2+ 1 (UniProtKB | ChEBI)
Binding site282Zn2+ 2 (UniProtKB | ChEBI)
Binding site322Zn2+ 2 (UniProtKB | ChEBI)
Binding site429Zn2+ 2 (UniProtKB | ChEBI)
Binding site463Zn2+ 2 (UniProtKB | ChEBI)
Binding site465Zn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular space
Cellular Componentlysosome
Molecular Functionacid sphingomyelin phosphodiesterase activity
Molecular Functionhydrolase activity, acting on glycosyl bonds
Molecular Functionmetal ion binding
Biological Processceramide biosynthetic process
Biological Processsphingomyelin catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sphingomyelin phosphodiesterase
  • EC number

Organism names

  • Taxonomic identifier
  • Strain
    • HLPLD3
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Scorpiones > Iurida > Scorpionoidea > Hemiscorpiidae

Accessions

  • Primary accession
    A0A1L4BJ95

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_501308626821-615Sphingomyelin phosphodiesterase
Disulfide bond92↔168
Disulfide bond95↔160
Disulfide bond123↔134
Disulfide bond225↔230
Disulfide bond231↔254
Disulfide bond389↔437
Disulfide bond589↔593

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain88-172Saposin B-type

Sequence similarities

Belongs to the acid sphingomyelinase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    615
  • Mass (Da)
    70,479
  • Last updated
    2017-03-15 v1
  • Checksum
    07CA88772991BE37
MRGLCVVLIVALSNLLLANCASLLFKKEYEREGSNLISHYNVDLSKNMQHFSKPNAREKRFLTDMVSFGVEMLNLKKAFRNVKQGVVNSLTCFACKFSVSLFQHFVEEGKSEEEIGHFADVICKTLRIESPRVCKGVTNSFRDEVVQVFSRIALSPKEVCGILLGDSCSKPYDPFFNWSVPLPSVPKPPSKQISAPKPGSPVLRVLHLSDTHFDHLYLEGSNANCKEPLCCRLADKVPANPEDRAGRWGDYRNCDTPLRTLEHMLKHISQNHKIDYVLWTGDIPAHDIWNQSRSDQVFFLRYISKLMSRYFKGIPIFPALGNHESFPVNSFPIPEITGNRSISWLYDELALAWRPWLPSSVLPSIKKGAYYSVKVNPGFRIISINMNYCNTLNWWLLINTTDPAQQLKWLVNELQTAEIQGEKVHIIGHIPPGASDCLQVWSQNYYKIINRYNDTIVAQFFGHTHMDEFEIFYDAASSYPTSIAYIGPSITTYDGVNPGYRIYTVDGNYPNSSRVVLDHETYYLNLTEANLTNKPIWRLEYTAKKAFNMTSLLASDWHKVVKEFLKNDNLFQKFYRYYRKMSDYFKEPCTGDCKAQLLCNLQSGRSHGSSFCRDI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KX932447
EMBL· GenBank· DDBJ
API81380.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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