A0A1L4AQQ4 · A0A1L4AQQ4_HUMAN

  • Protein
    Apoptosis regulator Bcl-2
  • Gene
    BCL2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentBcl-2 family protein complex
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial outer membrane
Cellular Componentnuclear membrane
Molecular Functionprotein heterodimerization activity
Molecular Functionprotein homodimerization activity
Biological Processextrinsic apoptotic signaling pathway in absence of ligand
Biological Processintrinsic apoptotic signaling pathway in response to DNA damage
Biological Processnegative regulation of intrinsic apoptotic signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Apoptosis regulator Bcl-2

Gene names

    • Name
      BCL2

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A1L4AQQ4

Subcellular Location

Cytoplasm
Endoplasmic reticulum membrane
; Single-pass membrane protein
Membrane
; Single-pass membrane protein
Mitochondrion outer membrane
; Single-pass membrane protein
Nucleus membrane
; Single-pass membrane protein

Keywords

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain, motif, region.

TypeIDPosition(s)Description
Domain11-30Apoptosis regulator Bcl-2 family BH4
Motif11-30BH4
Region39-85Disordered

Sequence similarities

Belongs to the Bcl-2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    195
  • Mass (Da)
    21,468
  • Last updated
    2017-03-15 v1
  • Checksum
    B63EB02AF7C8C245
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGW

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue195

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY098794
EMBL· GenBank· DDBJ
API71147.1
EMBL· GenBank· DDBJ
Genomic DNA
KY098814
EMBL· GenBank· DDBJ
API71167.1
EMBL· GenBank· DDBJ
Genomic DNA
KY098815
EMBL· GenBank· DDBJ
API71168.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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