A0A1L2BNB3 · A0A1L2BNB3_KONPU

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI
    • Synonyms
      cox1

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A0A1L2BNB3

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical
Transmembrane36-58Helical
Transmembrane92-112Helical
Transmembrane132-154Helical
Transmembrane166-193Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-218Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    218
  • Mass (Da)
    23,235
  • Last updated
    2017-03-15 v1
  • Checksum
    A98D8E5E2911C828
LYLVFGAWAGMVGTALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLSGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAISQYQTPLFVWAVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue218

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU302347
EMBL· GenBank· DDBJ
ALT07742.1
EMBL· GenBank· DDBJ
Genomic DNA
KU302348
EMBL· GenBank· DDBJ
ALT07743.1
EMBL· GenBank· DDBJ
Genomic DNA
KU302349
EMBL· GenBank· DDBJ
ALT07744.1
EMBL· GenBank· DDBJ
Genomic DNA
KU302350
EMBL· GenBank· DDBJ
ALT07745.1
EMBL· GenBank· DDBJ
Genomic DNA
KU302351
EMBL· GenBank· DDBJ
ALT07746.1
EMBL· GenBank· DDBJ
Genomic DNA
KU302352
EMBL· GenBank· DDBJ
ALT07747.1
EMBL· GenBank· DDBJ
Genomic DNA
KU302353
EMBL· GenBank· DDBJ
ALT07748.1
EMBL· GenBank· DDBJ
Genomic DNA
LC484872
EMBL· GenBank· DDBJ
BBK61002.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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