A0A1L1WKI0 · A0A1L1WKI0_OCHCU

Function

function

Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site185Proton donor
Binding site185-189AMP (UniProtKB | ChEBI)
Binding site189Zn2+ 1 (UniProtKB | ChEBI)
Binding site225Zn2+ 1 (UniProtKB | ChEBI)
Binding site226AMP (UniProtKB | ChEBI)
Binding site226Zn2+ 1 (UniProtKB | ChEBI)
Binding site226Zn2+ 2 (UniProtKB | ChEBI)
Binding site332AMP (UniProtKB | ChEBI)
Binding site332Zn2+ 1 (UniProtKB | ChEBI)
Binding site383AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentneuronal cell body
Molecular Function3',5'-cyclic-AMP phosphodiesterase activity
Molecular Functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
Molecular Functionmetal ion binding
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Organism names

  • Taxonomic identifier
  • Strain
    • Gyst
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Ochotonidae > Ochotona

Accessions

  • Primary accession
    A0A1L1WKI0

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for coiled coil, domain, region, compositional bias.

Type
IDPosition(s)Description
Coiled coil1-53
Domain108-458PDEase
Region408-429Disordered
Compositional bias412-426Polar residues

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    458
  • Mass (Da)
    52,872
  • Last updated
    2017-03-15 v1
  • MD5 Checksum
    6C75C57911E6977FFCC9A4C838FBC8CF
LRYMVKQLENGEVNIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVHNCLKNLDLWCFDVFSLNRASEDHALRTIVFELLTRHNLISRFKIPTVFLMTFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFRMMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWPVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLVDDDSKSKNQPSFQWRQPSLDVDVGDPNPDVVSFRSTWTKYIQENKQKW

Features

Showing features for non-terminal residue, compositional bias.

Type
IDPosition(s)Description
Non-terminal residue1
Compositional bias412-426Polar residues
Non-terminal residue458

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ160400
EMBL· GenBank· DDBJ
AIZ76571.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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