A0A1L1WKI0 · A0A1L1WKI0_OCHCU
- ProteinPhosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids458 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
- 3',5'-cyclic GMP + H2O = GMP + H+This reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 185 | Proton donor | |||
Binding site | 185-189 | AMP (UniProtKB | ChEBI) | |||
Binding site | 189 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 225 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 226 | AMP (UniProtKB | ChEBI) | |||
Binding site | 226 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 226 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 332 | AMP (UniProtKB | ChEBI) | |||
Binding site | 332 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 383 | AMP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | neuronal cell body | |
Molecular Function | 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Ochotonidae > Ochotona
Accessions
- Primary accessionA0A1L1WKI0
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for coiled coil, domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Coiled coil | 1-53 | ||||
Domain | 108-458 | PDEase | |||
Region | 408-429 | Disordered | |||
Compositional bias | 412-426 | Polar residues | |||
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length458
- Mass (Da)52,872
- Last updated2017-03-15 v1
- MD5 Checksum6C75C57911E6977FFCC9A4C838FBC8CF
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Compositional bias | 412-426 | Polar residues | |||
Non-terminal residue | 458 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KJ160400 EMBL· GenBank· DDBJ | AIZ76571.1 EMBL· GenBank· DDBJ | mRNA |