Matriptase drives early-onset intestinal failure in a mouse model of congenital tufting enteropathy.Szabo R., Callies L.K., Bugge T.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCDevelopment 146:dev183392-dev183392 (2019)Mapped to11
Inflammatory cytokines down-regulate the barrier-protective prostasin- matriptase proteolytic cascade early in experimental colitis.Buzza M.S., Johnson T.A., Conway G.D., Martin E.W., Mukhopadhyay S., Shea-Donohue T., Antalis T.M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCJ Biol Chem 292:10801-10812 (2017)Mapped to33
Delineation of proteolytic and non-proteolytic functions of the membrane- anchored serine protease prostasin.Szabo R., Lantsman T., Peters D.E., Bugge T.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCDevelopment 143:2818-2828 (2016)Mapped to13
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.Koscielny G., Yaikhom G., Iyer V., Meehan T.F., Morgan H., Atienza-Herrero J., Blake A., Chen C.K., Easty R.[...], Parkinson H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCNucleic Acids Res 42:D802-9 (2014)Mapped to99+
Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation.Szabo R., Uzzun Sales K., Kosa P., Shylo N.A., Godiksen S., Hansen K.K., Friis S., Gutkind J.S., Vogel L.K.[...], Bugge T.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCPLoS Genet 8:e1002937-e1002937 (2012)Mapped to29
Matriptase protects against experimental colitis and promotes intestinal barrier recovery.Netzel-Arnett S., Buzza M.S., Shea-Donohue T., Desilets A., Leduc R., Fasano A., Bugge T.H., Antalis T.M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCInflamm Bowel Dis 18:1303-1314 (2012)Mapped to16
Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality.Szabo R., Kosa P., List K., Bugge T.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCAm J Pathol 174:2015-2022 (2009)Mapped to6
Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota.Scharschmidt T.C., List K., Grice E.A., Szabo R., Renaud G., Lee C.C., Wolfsberg T.G., Bugge T.H., Segre J.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCJ Invest Dermatol 129:2435-2442 (2009)Mapped to4
Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice.Nagaike K., Kawaguchi M., Takeda N., Fukushima T., Sawaguchi A., Kohama K., Setoyama M., Kataoka H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCAm J Pathol 173:1464-1475 (2008)Mapped to41
EUCOMM--the European conditional mouse mutagenesis program.Friedel R.H., Seisenberger C., Kaloff C., Wurst W.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCBrief Funct Genomic Proteomic 6:180-185 (2007)Mapped to99+
Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice.List K., Currie B., Scharschmidt T.C., Szabo R., Shireman J., Molinolo A., Cravatt B.F., Segre J., Bugge T.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCJ Biol Chem 282:36714-36723 (2007)Mapped to15
Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development.Szabo R., Molinolo A., List K., Bugge T.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCOncogene 26:1546-1556 (2007)Mapped to31
Phenotypic analysis of mice lacking the Tmprss2-encoded protease.Kim T.S., Heinlein C., Hackman R.C., Nelson P.S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCMol. Cell. Biol. 26:965-975 (2006)Cited in1Mapped to45
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.Zambrowicz B.P., Abuin A., Ramirez-Solis R., Richter L.J., Piggott J., BeltrandelRio H., Buxton E.C., Edwards J., Finch R.A.[...], Sands A.T.View abstractCategoriesPhenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 100:14109-14114 (2003)Cited in1Mapped to99+
Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis.List K., Haudenschild C.C., Szabo R., Chen W., Wahl S.M., Swaim W., Engelholm L.H., Behrendt N., Bugge T.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1338881PubMedEurope PMCOncogene 21:3765-3779 (2002)Mapped to4