A0A1J9PTN8 · A0A1J9PTN8_9BURK

  • Protein
    Enoyl-[acyl-carrier-protein] reductase [NADH]
  • Gene
    fabV
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Lipid metabolism; fatty acid biosynthesis.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site48-53NAD+ (UniProtKB | ChEBI)
Binding site74-75NAD+ (UniProtKB | ChEBI)
Site75Plays an important role in discriminating NADH against NADPH
Binding site111-112NAD+ (UniProtKB | ChEBI)
Binding site139-140NAD+ (UniProtKB | ChEBI)
Binding site225substrate
Active site235Proton donor
Binding site244NAD+ (UniProtKB | ChEBI)
Binding site273-275NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
Molecular FunctionNAD binding
Molecular Functiontrans-2-enoyl-CoA reductase (NADH) activity
Biological Processfatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Enoyl-[acyl-carrier-protein] reductase [NADH]
  • EC number
  • Short names
    ENR

Gene names

    • Name
      fabV
    • ORF names
      BFF94_25555

Organism names

  • Taxonomic identifier
  • Strain
    • DNA89
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex

Accessions

  • Primary accession
    A0A1J9PTN8

Proteomes

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-80Trans-2-enoyl-CoA reductase-like NAD(P)H binding
Domain82-317Trans-2-enoyl-CoA reductase catalytic
Domain323-386Enoyl reductase FAD binding

Sequence similarities

Belongs to the TER reductase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    400
  • Mass (Da)
    43,377
  • Last updated
    2017-02-15 v1
  • MD5 Checksum
    6C7BE959D7AE5830F933AA3E8ADE299D
MIIKPRVRGFICVTTHPVGCEASVKEQIDYVTSHGPIANGPKKVLVIGASTGYGLAARISAAFGSGADTLGVFFERAGSETKPGTAGWYNSAAFEKFAAEKGHYARSINGDAFSDKVKQITIDTIKQDLGKVDLVVYSLAAPRRTHPKTGETISSTLKPIGKAVTFRGLDTDKEVIREVSLEPATQEEIDGTVAVMGGEDWQMWIDALDEAGVLADGAKTTAFTYLGEQITHDIYWNGSIGEAKKDLDKKVLSIREKLAAHGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKVMKETGTHEGCIEQVYGLLKDSLYGATPHVDEEGRLRADYKELDPQVQAKVVAMWDKVTNENLYELTDFAGYKSDFLRLFGFEIAGVDYDADVNPDVKIPGIIDTTI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MDEQ01000137
EMBL· GenBank· DDBJ
OJD07295.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help