A0A1J9PTN8 · A0A1J9PTN8_9BURK
- ProteinEnoyl-[acyl-carrier-protein] reductase [NADH]
- GenefabV
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids400 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
Catalytic activity
- a 2,3-saturated acyl-CoA + NAD+ = a (2E)-enoyl-CoA + NADH + H+
Pathway
Lipid metabolism; fatty acid biosynthesis.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 48-53 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 74-75 | NAD+ (UniProtKB | ChEBI) | |||
Site | 75 | Plays an important role in discriminating NADH against NADPH | |||
Binding site | 111-112 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 139-140 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 225 | substrate | |||
Active site | 235 | Proton donor | |||
Binding site | 244 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 273-275 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | enoyl-[acyl-carrier-protein] reductase (NADH) activity | |
Molecular Function | NAD binding | |
Molecular Function | trans-2-enoyl-CoA reductase (NADH) activity | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEnoyl-[acyl-carrier-protein] reductase [NADH]
- EC number
- Short namesENR
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex
Accessions
- Primary accessionA0A1J9PTN8
Proteomes
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 2-80 | Trans-2-enoyl-CoA reductase-like NAD(P)H binding | |||
Domain | 82-317 | Trans-2-enoyl-CoA reductase catalytic | |||
Domain | 323-386 | Enoyl reductase FAD binding | |||
Sequence similarities
Belongs to the TER reductase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length400
- Mass (Da)43,377
- Last updated2017-02-15 v1
- MD5 Checksum6C7BE959D7AE5830F933AA3E8ADE299D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MDEQ01000137 EMBL· GenBank· DDBJ | OJD07295.1 EMBL· GenBank· DDBJ | Genomic DNA |