A0A1J9PE91 · A0A1J9PE91_9EURO

Function

function

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentendosome membrane
Cellular Componentextrinsic component of membrane
Cellular Componentfungal-type vacuole membrane
Cellular Componentphagophore assembly site membrane
Molecular Functionphosphatidylinositol-3,5-bisphosphate binding
Molecular Functionphosphatidylinositol-3-phosphate binding
Biological Processautophagy of mitochondrion
Biological Processnucleophagy
Biological Processprotein lipidation
Biological Processprotein localization to phagophore assembly site

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Autophagy-related protein 18

Gene names

    • ORF names
      AJ78_05317

Organism names

  • Taxonomic identifier
  • Strain
    • UAMH 9510
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Ajellomycetaceae > Emergomyces

Accessions

  • Primary accession
    A0A1J9PE91

Proteomes

Organism-specific databases

Subcellular Location

Endosome membrane
; Peripheral membrane protein
Preautophagosomal structure membrane
; Peripheral membrane protein
Vacuole membrane
; Peripheral membrane protein

Keywords

  • Cellular component

Interaction

Subunit

Component of the PI(3,5)P2 regulatory complex.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region266-317Disordered
Compositional bias285-302Polar residues

Sequence similarities

Belongs to the WD repeat PROPPIN family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    422
  • Mass (Da)
    45,694
  • Last updated
    2017-02-15 v1
  • MD5 Checksum
    A9252843C03792B4DED151906904082D
MAMNFVTFNQDYSYLAVGTSKGFRIFTTDPFAKSYETKEGNIAILEMLFSTSLVALILSPRRLQITNTKRQSTICELTFPTTVLAVRLNRKRLVIVLEDQIYLYDIQTMKLLYTIETSPNPNAICTLSPSSENCYLAYPLPQKAPPSSFTPPSHAPPSSTHISPTSGEVLIFDTLKLEAINVVEAHKSPLSCLAMNTEGTLLATASDKGTIIRVFSVPDAHKLYQFRRGSMPSRIFSMSFNITSTLLCVSSATETIHIFKLGHQGTSEELPASPIGADPRSPSSATRERGLSQSSSTFSAGEDPATDADPGDISARKHNGTLMGMIRRTSQNVGNSFAATVGGYLPKGVTEMWEPARDFAWIKLPKTAGQGSPGSNAGPVRSVVAMSSNTPQVMVVTSDGNFYVFNVDLSKGGEGTLTKQYS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias285-302Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LGRN01000227
EMBL· GenBank· DDBJ
OJD14322.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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