A0A1J7JDY3 · A0A1J7JDY3_9PEZI

Function

function

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasmic microtubule
Cellular Componentkinetochore
Cellular Componentmicrotubule associated complex
Cellular Componentnuclear envelope
Cellular Componentspindle pole
Molecular Functiondynein complex binding
Molecular Functionmicrotubule plus-end binding
Biological Processcell division
Biological Processestablishment of mitotic spindle orientation
Biological Processmicrotubule organizing center organization
Biological Processmicrotubule sliding
Biological Processnuclear migration
Biological Processvesicle transport along microtubule

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear distribution protein PAC1
  • Alternative names
    • Lissencephaly-1 homolog
      (LIS-1
      )
    • nudF homolog

Gene names

    • Name
      PAC1
    • Synonyms
      LIS1
    • ORF names
      CONLIGDRAFT_655588

Organism names

  • Taxonomic identifier
  • Strain
    • NRRL 30616
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Coniochaetales > Coniochaetaceae > Coniochaeta

Accessions

  • Primary accession
    A0A1J7JDY3

Proteomes

Subcellular Location

Cytoplasm, cytoskeleton
Note: Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.

Keywords

Interaction

Subunit

Self-associates. Interacts with NDL1 and dynein.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, repeat, compositional bias.

TypeIDPosition(s)Description
Region81-100Disordered
Repeat112-153WD
Repeat154-188WD
Repeat199-248WD
Repeat249-283WD
Repeat355-389WD
Compositional bias420-435Polar residues
Region420-441Disordered

Domain

Dimerization mediated by the LisH domain may be required to activate dynein.

Sequence similarities

Belongs to the WD repeat LIS1/nudF family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    469
  • Mass (Da)
    50,715
  • Last updated
    2017-02-15 v1
  • Checksum
    67F722BB05BFBD4C
MTQILTTRQAEELHKSIIAYLSANNLSNAAAALRADVGLGEDVFDTNTAKKYEGLLEKKWTSVVRLQKKIMDLESRNATLQSEIDNATPTSLSKRNQDPVSWLPRSPARHNLQSHRSAITSVAFHPIFSSLASGSEDCTIKIWDWELGELERTIKGHTKAVLDLDFGGPRGGTLLASCSSDLTIKLWDPADEYKNIRTLPGHDHSVSAVRFIPSGAAGAPASGNLLVSASRDKTLRIWDVSTGYCVKTLRGHADWVRDVCPSLDGRFLLSAGVDQSARLWDISLSTPETKVTLFGHEHTIECCVIAPPAAYQYLAPLAGLKKPPPASSPAEFMATGSRDKLIKLWDGRGNCIKTLVGHDNWVRGLVFHPGGKYLLSVADDYSLRCWDLSQEGKCVKTLGDAHGHFVSCIRWAPSIIKNDPAANGNGTSGQNGGEANGTPKKGAIAAPEVQIRCVLATGSVDTSVRVFAN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias420-435Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KV875099
EMBL· GenBank· DDBJ
OIW27912.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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