A0A1J7JDY3 · A0A1J7JDY3_9PEZI
- ProteinNuclear distribution protein PAC1
- GenePAC1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids469 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic microtubule | |
Cellular Component | kinetochore | |
Cellular Component | microtubule associated complex | |
Cellular Component | nuclear envelope | |
Cellular Component | spindle pole | |
Molecular Function | dynein complex binding | |
Molecular Function | microtubule plus-end binding | |
Biological Process | cell division | |
Biological Process | establishment of mitotic spindle orientation | |
Biological Process | microtubule organizing center organization | |
Biological Process | microtubule sliding | |
Biological Process | nuclear migration | |
Biological Process | vesicle transport along microtubule |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameNuclear distribution protein PAC1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Coniochaetales > Coniochaetaceae > Coniochaeta
Accessions
- Primary accessionA0A1J7JDY3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.
Keywords
- Cellular component
Interaction
Structure
Family & Domains
Features
Showing features for region, repeat, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 81-100 | Disordered | ||||
Sequence: QSEIDNATPTSLSKRNQDPV | ||||||
Repeat | 112-153 | WD | ||||
Sequence: LQSHRSAITSVAFHPIFSSLASGSEDCTIKIWDWELGELERT | ||||||
Repeat | 154-188 | WD | ||||
Sequence: IKGHTKAVLDLDFGGPRGGTLLASCSSDLTIKLWD | ||||||
Repeat | 199-248 | WD | ||||
Sequence: LPGHDHSVSAVRFIPSGAAGAPASGNLLVSASRDKTLRIWDVSTGYCVKT | ||||||
Repeat | 249-283 | WD | ||||
Sequence: LRGHADWVRDVCPSLDGRFLLSAGVDQSARLWDIS | ||||||
Repeat | 355-389 | WD | ||||
Sequence: LVGHDNWVRGLVFHPGGKYLLSVADDYSLRCWDLS | ||||||
Compositional bias | 420-435 | Polar residues | ||||
Sequence: PAANGNGTSGQNGGEA | ||||||
Region | 420-441 | Disordered | ||||
Sequence: PAANGNGTSGQNGGEANGTPKK |
Domain
Dimerization mediated by the LisH domain may be required to activate dynein.
Sequence similarities
Belongs to the WD repeat LIS1/nudF family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length469
- Mass (Da)50,715
- Last updated2017-02-15 v1
- Checksum67F722BB05BFBD4C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 420-435 | Polar residues | ||||
Sequence: PAANGNGTSGQNGGEA |
Keywords
- Technical term