A0A1J4NJA2 · A0A1J4NJA2_9GAMM

Function

function

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site50-54GTP (UniProtKB | ChEBI)
Binding site55Zn2+ (UniProtKB | ChEBI); catalytic
Binding site66Zn2+ (UniProtKB | ChEBI); catalytic
Binding site68Zn2+ (UniProtKB | ChEBI); catalytic
Binding site71GTP (UniProtKB | ChEBI)
Binding site93-95GTP (UniProtKB | ChEBI)
Binding site115GTP (UniProtKB | ChEBI)
Active site127Proton acceptor
Active site129Nucleophile
Binding site150GTP (UniProtKB | ChEBI)
Binding site155GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function3,4-dihydroxy-2-butanone-4-phosphate synthase activity
Molecular FunctionGTP binding
Molecular FunctionGTP cyclohydrolase II activity
Molecular Functionzinc ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP cyclohydrolase-2
  • EC number
  • Alternative names
    • GTP cyclohydrolase II

Gene names

    • Name
      ribA
    • ORF names
      BK820_00975

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LCT-H3
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter

Accessions

  • Primary accession
    A0A1J4NJA2

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-171GTP cyclohydrolase II

Sequence similarities

Belongs to the GTP cyclohydrolase II family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    200
  • Mass (Da)
    22,282
  • Last updated
    2017-02-15 v1
  • Checksum
    60E2AC785796EE56
MPIEFVATSRLPTAHGEFKITVFQDPKTGEEHVALSKGLEESSDEPVLVRVHSECLTGDAFASLKCDCGPQLQATQKLINEVGRGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLMLNLPADARQYDMCSIMLDHLGVKAVRLITNNPTKINALKDLGINVVDRVPLTVGLNPFNEQYLKTKHERMAHLYRKDDF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MODX01000001
EMBL· GenBank· DDBJ
OIJ39358.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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