A0A1J4NGR6 · A0A1J4NGR6_9GAMM

  • Protein
    Betaine aldehyde dehydrogenase
  • Gene
    betB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 2 potassium ions per subunit.

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site26K+ 1 (UniProtKB | ChEBI)
Binding site27K+ 1 (UniProtKB | ChEBI)
Binding site93K+ 1 (UniProtKB | ChEBI)
Binding site150-152NAD+ (UniProtKB | ChEBI)
Active site162Charge relay system
Binding site229-232NAD+ (UniProtKB | ChEBI)
Binding site245K+ 2 (UniProtKB | ChEBI)
Site247Seems to be a necessary countercharge to the potassium cations
Active site251
Active site251Proton acceptor
Binding site253NAD+ (UniProtKB | ChEBI)
Active site285Nucleophile
Binding site285NAD+ (UniProtKB | ChEBI); covalent
Binding site386NAD+ (UniProtKB | ChEBI)
Binding site456K+ 2 (UniProtKB | ChEBI)
Binding site459K+ 2 (UniProtKB | ChEBI)
Active site463Charge relay system

GO annotations

AspectTerm
Molecular Functionbetaine-aldehyde dehydrogenase (NAD+) activity
Molecular Functionmetal ion binding
Biological Processglycine betaine biosynthetic process from choline

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Betaine aldehyde dehydrogenase
  • EC number
  • Short names
    BADH

Gene names

    • Name
      betB
    • ORF names
      BK820_04935

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LCT-H3
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter

Accessions

  • Primary accession
    A0A1J4NGR6

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue285Cysteine sulfenic acid (-SOH)

Keywords

Interaction

Subunit

Dimer of dimers.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-478Aldehyde dehydrogenase

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    491
  • Mass (Da)
    53,275
  • Last updated
    2017-02-15 v1
  • Checksum
    543E21074651C2D0
MTHFNLQRPYIHGQFVDATSNSTFETINPATGEVLAEVQICSKDDIDRAVKSAQQGQKVWAEMTAIQRSRILQKAVAILRDRNDELARIETLDSGKAFSETSTVDIATGADVLEYYAGILPALEGQQIPLRETSFIYTRREPLGVVAGIGAWNYPIQIALWKSAPAMAAGNAMIFKASEVTPLTALKLAEIYTEAGVPHGVFNVVTGGSEIGAYLTSHPDIAKVSFTGGVATGKKVMAQAANSSLKEVTMELGGKSPLIICEDADLDLAADIAMMANYYSSGQVCTNGTRVFIPLALKAEFEDKILQRIPYVRMGDPLDPETNFGPVSSFSHMAKVLDYIEQGKKEGARLLCGGGRAEDEQFAQGAYVLPTVFTDCRDDMTIVRDEIFGPVMSILSYDSEEEVIQRANATEYGLAAGVVTPNLSRAHRIIHQIEAGICWINTWGESPAEMPVGGYKHSGVGRENGIVTLQQYTQTKSVQVELSPFQSVFNA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MODX01000006
EMBL· GenBank· DDBJ
OIJ38474.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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