A0A1J4NG34 · A0A1J4NG34_9GAMM
- ProteinDihydroorotate dehydrogenase (quinone)
- GenepyrD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids333 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Catalytic activity
- (S)-dihydroorotate + a quinone = a quinol + orotate
Cofactor
Note: Binds 1 FMN per subunit.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 59-63 | FMN (UniProtKB | ChEBI) | ||||
Sequence: AGLDK | ||||||
Binding site | 63 | substrate | ||||
Sequence: K | ||||||
Binding site | 83 | FMN (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 108-112 | substrate | ||||
Sequence: NRMGF | ||||||
Binding site | 136 | FMN (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 169 | FMN (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 169 | substrate | ||||
Sequence: N | ||||||
Active site | 172 | Nucleophile | ||||
Sequence: S | ||||||
Binding site | 174 | substrate | ||||
Sequence: N | ||||||
Binding site | 214 | FMN (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 242 | FMN (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 243-244 | substrate | ||||
Sequence: NT | ||||||
Binding site | 265 | FMN (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 294 | FMN (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 315-316 | FMN (UniProtKB | ChEBI) | ||||
Sequence: YS |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | dihydroorotate dehydrogenase (quinone) activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydroorotate dehydrogenase (quinone)
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter
Accessions
- Primary accessionA0A1J4NG34
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 44-329 | Dihydroorotate dehydrogenase catalytic | ||||
Sequence: VTCMGIEFPNPVGLAAGLDKNGAYIDALASQGFGFIEIGTITPRPQPGNPEPRLFRLPKAKAIINRMGFNNEGVDKLIENVKAAKFKGVLGINIGKNAVTPVENAVDDYLICLEKVYNYASYITVNISSPNTKNLRSLQSGDALTELLETLKNRQLELAQENQHYVPLVLKVAPDLEAEDITFIAQQLLQFKIDGLIVTNTTLSREGVEGLEYAEEAGGLSGAPVFEKSTACLKAFADVLQGQIPLIGVGGILSGADAAAKKQAGASLVQVYSGLIYTGPTLVKDC |
Sequence similarities
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length333
- Mass (Da)35,706
- Last updated2017-02-15 v1
- ChecksumBB362467D0E67ED8