A0A1J4NG34 · A0A1J4NG34_9GAMM

  • Protein
    Dihydroorotate dehydrogenase (quinone)
  • Gene
    pyrD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site59-63FMN (UniProtKB | ChEBI)
Binding site63substrate
Binding site83FMN (UniProtKB | ChEBI)
Binding site108-112substrate
Binding site136FMN (UniProtKB | ChEBI)
Binding site169FMN (UniProtKB | ChEBI)
Binding site169substrate
Active site172Nucleophile
Binding site174substrate
Binding site214FMN (UniProtKB | ChEBI)
Binding site242FMN (UniProtKB | ChEBI)
Binding site243-244substrate
Binding site265FMN (UniProtKB | ChEBI)
Binding site294FMN (UniProtKB | ChEBI)
Binding site315-316FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functiondihydroorotate dehydrogenase (quinone) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase (quinone)
  • EC number
  • Alternative names
    • DHOdehase
      (DHOD
      ; DHODase
      )
    • Dihydroorotate oxidase

Gene names

    • Name
      pyrD
    • ORF names
      BK820_06795

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LCT-H3
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter

Accessions

  • Primary accession
    A0A1J4NG34

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain44-329Dihydroorotate dehydrogenase catalytic

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    333
  • Mass (Da)
    35,706
  • Last updated
    2017-02-15 v1
  • Checksum
    BB362467D0E67ED8
MLYSLARPLLFSLAPERAHELTLSLLKSSHAMGMMRQNVASKPVTCMGIEFPNPVGLAAGLDKNGAYIDALASQGFGFIEIGTITPRPQPGNPEPRLFRLPKAKAIINRMGFNNEGVDKLIENVKAAKFKGVLGINIGKNAVTPVENAVDDYLICLEKVYNYASYITVNISSPNTKNLRSLQSGDALTELLETLKNRQLELAQENQHYVPLVLKVAPDLEAEDITFIAQQLLQFKIDGLIVTNTTLSREGVEGLEYAEEAGGLSGAPVFEKSTACLKAFADVLQGQIPLIGVGGILSGADAAAKKQAGASLVQVYSGLIYTGPTLVKDCVEAF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MODX01000009
EMBL· GenBank· DDBJ
OIJ38145.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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