A0A1J4MFP8 · A0A1J4MFP8_9CRYT
- ProteinDNA topoisomerase 2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1789 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Catalytic activity
Cofactor
Protein has several cofactor binding sites:
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA topological change |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 2
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Cryptosporidiidae > Cryptosporidium
Accessions
- Primary accessionA0A1J4MFP8
Proteomes
Organism-specific databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 313-347 | Basic and acidic residues | ||||
Sequence: NNEKRNNTRKLRNANKKNVKSDGEDENSNGFNEND | ||||||
Region | 313-406 | Disordered | ||||
Sequence: NNEKRNNTRKLRNANKKNVKSDGEDENSNGFNENDHDESFEEDFMEDDEWDDEPKTSRSKKKSSVSNSKKKKSGQNISSSFFSSSSSSSSSLLL | ||||||
Compositional bias | 348-362 | Acidic residues | ||||
Sequence: HDESFEEDFMEDDEW | ||||||
Compositional bias | 381-406 | Polar residues | ||||
Sequence: KKKKSGQNISSSFFSSSSSSSSSLLL | ||||||
Domain | 589-704 | Toprim | ||||
Sequence: CTLILTEGDSAKTSCLAGLSIVGRDYFGVFPLRGKLLNVREASFKQQIGNVEIQNILKILGLGIGQKYDNGPVNLRYGSLMLMTDQDHDGSHIKGLIINLIHYYWPSLIHFRGFLK | ||||||
Coiled coil | 1371-1428 | |||||
Sequence: MELLEAELLKKTEEYEKLLKTGIEEIWNIELDELLKVIEEEETQEEMIEAEHNSLIQK | ||||||
Region | 1442-1599 | Disordered | ||||
Sequence: TGTSRKRRNETAKKQENIKAKHPQKTNSKKTTKPTKKSRIGDSESDEYIEGDDYSEEDHHYGDFDDVLDGSDDSNDFDDIDNFESSDSEKEGIDDPESEFEDFSDSGKTSKGRRTQKVSIKKSKSGVQGKTNSSNVKKAKNISSSLSNSSKENKQGLF | ||||||
Compositional bias | 1449-1464 | Basic and acidic residues | ||||
Sequence: RNETAKKQENIKAKHP | ||||||
Compositional bias | 1509-1542 | Acidic residues | ||||
Sequence: LDGSDDSNDFDDIDNFESSDSEKEGIDDPESEFE | ||||||
Compositional bias | 1562-1598 | Polar residues | ||||
Sequence: KKSKSGVQGKTNSSNVKKAKNISSSLSNSSKENKQGL | ||||||
Compositional bias | 1664-1694 | Polar residues | ||||
Sequence: NQSHSSFSSSLNKVTSTDNSSKENGPVSKQT | ||||||
Region | 1664-1789 | Disordered | ||||
Sequence: NQSHSSFSSSLNKVTSTDNSSKENGPVSKQTKITDIFKKGAIGDSENGVAKSVNQKKQNNQISRTKGVPTSKRGRRKTIIESEDEEEEEEEEEEEEEEEEEEDGIEDNESFSDVSSDSLMESDFSE | ||||||
Compositional bias | 1711-1731 | Polar residues | ||||
Sequence: GVAKSVNQKKQNNQISRTKGV | ||||||
Compositional bias | 1746-1773 | Acidic residues | ||||
Sequence: EDEEEEEEEEEEEEEEEEEEDGIEDNES | ||||||
Compositional bias | 1774-1789 | Polar residues | ||||
Sequence: FSDVSSDSLMESDFSE |
Sequence similarities
Belongs to the type II topoisomerase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,789
- Mass (Da)203,891
- Last updated2017-02-15 v1
- Checksum21C77C9A8735E791
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 313-347 | Basic and acidic residues | ||||
Sequence: NNEKRNNTRKLRNANKKNVKSDGEDENSNGFNEND | ||||||
Compositional bias | 348-362 | Acidic residues | ||||
Sequence: HDESFEEDFMEDDEW | ||||||
Compositional bias | 381-406 | Polar residues | ||||
Sequence: KKKKSGQNISSSFFSSSSSSSSSLLL | ||||||
Compositional bias | 1449-1464 | Basic and acidic residues | ||||
Sequence: RNETAKKQENIKAKHP | ||||||
Compositional bias | 1509-1542 | Acidic residues | ||||
Sequence: LDGSDDSNDFDDIDNFESSDSEKEGIDDPESEFE | ||||||
Compositional bias | 1562-1598 | Polar residues | ||||
Sequence: KKSKSGVQGKTNSSNVKKAKNISSSLSNSSKENKQGL | ||||||
Compositional bias | 1664-1694 | Polar residues | ||||
Sequence: NQSHSSFSSSLNKVTSTDNSSKENGPVSKQT | ||||||
Compositional bias | 1711-1731 | Polar residues | ||||
Sequence: GVAKSVNQKKQNNQISRTKGV | ||||||
Compositional bias | 1746-1773 | Acidic residues | ||||
Sequence: EDEEEEEEEEEEEEEEEEEEDGIEDNES | ||||||
Compositional bias | 1774-1789 | Polar residues | ||||
Sequence: FSDVSSDSLMESDFSE |