A0A1J1GZ99 · A0A1J1GZ99_PLAGA
- ProteinDNA replication licensing factor MCM4
- GeneMCM4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids952 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | MCM complex | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | hydrolase activity | |
Molecular Function | single-stranded DNA binding | |
Molecular Function | single-stranded DNA helicase activity | |
Biological Process | DNA strand elongation involved in DNA replication | |
Biological Process | DNA unwinding involved in DNA replication | |
Biological Process | double-strand break repair via break-induced replication | |
Biological Process | mitotic DNA replication initiation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA replication licensing factor MCM4
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Haemamoeba)
Accessions
- Primary accessionA0A1J1GZ99
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Interaction
Subunit
Component of the MCM2-7 complex.
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 504-710 | MCM | |||
Compositional bias | 718-736 | Acidic residues | |||
Region | 718-764 | Disordered | |||
Compositional bias | 741-764 | Polar residues | |||
Sequence similarities
Belongs to the MCM family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length952
- Mass (Da)108,883
- Last updated2017-02-15 v1
- MD5 ChecksumC444048467842AE832BD5CDEAEDBFA1C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 718-736 | Acidic residues | |||
Compositional bias | 741-764 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CVMV01000110 EMBL· GenBank· DDBJ | CRG97561.1 EMBL· GenBank· DDBJ | Genomic DNA |