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A0A1J1GZ99 · A0A1J1GZ99_PLAGA

  • Protein
    DNA replication licensing factor MCM4
  • Gene
    MCM4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Catalytic activity

GO annotations

AspectTerm
Cellular ComponentMCM complex
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionhydrolase activity
Molecular Functionsingle-stranded DNA binding
Molecular Functionsingle-stranded DNA helicase activity
Biological ProcessDNA strand elongation involved in DNA replication
Biological ProcessDNA unwinding involved in DNA replication
Biological Processdouble-strand break repair via break-induced replication
Biological Processmitotic DNA replication initiation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA replication licensing factor MCM4
  • EC number

Gene names

    • Name
      MCM4
    • ORF names
      PGAL8A_00513400

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 8A
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Haemamoeba)

Accessions

  • Primary accession
    A0A1J1GZ99

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Component of the MCM2-7 complex.

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain504-710MCM
Compositional bias718-736Acidic residues
Region718-764Disordered
Compositional bias741-764Polar residues

Sequence similarities

Belongs to the MCM family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    952
  • Mass (Da)
    108,883
  • Last updated
    2017-02-15 v1
  • MD5 Checksum
    C444048467842AE832BD5CDEAEDBFA1C
MGTPRRRAGQNASPFGLSSNIFGTNNEIFGSNFMNSPISSRRTKNSKSFLNSMLNESKYLNQSNTGSQFIRYGHTPLAIRRIKCARADIGDVGREAFMEDIESGRLPHFIDSNLEQIKELFNQFFDEFNITNYSDVLQFTDEDRSITEYILLHRDNLKVYLAYYGWKMIKFIETGRQNECKLNNDNDEDTDGVKNLEHIKSFEVDLTHIYFFNKKLYKLIIEYPSDCISEIDKIISEKYNSLLGLVLEGDTKSSSSDKYPLSSAKQDYCRVRFFNKKHKDTPRKLGPNQIETLVCVKGVIIRCSNIIPEMTMAAFKCTSKKRVGVNNYEKCNEEVYEHVIQGEVQEPMTCSNCNNKNTFELWHNNCCFSSKQLIKLSEVTEHLKQGETPQSISIYAYDDLIDYTKPGDTVELTGILKASPVRLNPRSRCYNSVHRTYINVIHIKKENKQKMKLTEQNDTASIILKRNEDGTVEENFEKLNEQGNLLFTTEVIHKMQKLSKDPNIYQRLADSIAPSIYGRDDIKKGLLCQLFGGSKITDKFRNKYRSEIHILLCGDPSTAKSQLLHYVHKLSPRGIYTSGKGSSSVGLTAFISKDSETKEYILESGAVVLSDKGICCIDEFDKMDDSARAILHEVMEQQTVTIAKAGIVATLNARTSVLASANPINSRYDKNKAVVENINLPPSLFSRFDLIYLVIDQANEEEDKKLATVLCKNYSYNLEDEEEEEEEEEEEEEDTQNKENNWNIRDNINLPYSDNNNSSNKKKPKNYLIDSNTLALYIAYCRMTCNPIISLESKKIIIEEYIKMRCKEGTKSPTASPRQLEGLVRLSQSLAKMKLKDVVTPEEANEAVRLMNIATFQSLIDPLSGRIDFDQVNLGQTSQHKKKSDMIKDIIMNALILKNMTKDELLAHCQETIMNDPEYTTALDRKSFEEAFHDLEKSQDITRLCSGLYKKK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias718-736Acidic residues
Compositional bias741-764Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CVMV01000110
EMBL· GenBank· DDBJ
CRG97561.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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