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A0A1J1GVF6 · A0A1J1GVF6_PLAGA

  • Protein
    Circumsporozoite protein
  • Gene
    CSP
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.

Circumsporozoite protein C-terminus

In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Cellular Componentside of membrane

Names & Taxonomy

Protein names

Gene names

    • Name
      CSP
    • ORF names
      PGAL8A_00003900

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 8A
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Haemamoeba)

Accessions

  • Primary accession
    A0A1J1GVF6

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor
Cytoplasm
Note: Localizes to the cytoplasm and the cell membrane in oocysts at day 6 post infection and then gradually distributes over the entire cell surface of the sporoblast and the budding sporozoites.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane483-504Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-15
ChainPRO_501215894816-505Circumsporozoite protein

Keywords

Expression

Keywords

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias85-103Polar residues
Region85-104Disordered
Region121-421Disordered
Compositional bias391-406Basic and acidic residues

Domain

The GPI-anchor is essential for cell membrane localization and for sporozoite formation inside the oocyst.
The N-terminus is involved in the initial binding to heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes. The N-terminus masks the TSP type-1 (TSR) domain which maintains the sporozoites in a migratory state, enabling them to complete their journey to the salivary gland in the mosquito vector and then to the host liver. The unmasking of the TSP type-1 (TSR) domain when the sporozoite interacts with the host hepatocyte also protects sporozoites from host antibodies.
The TSP type-1 (TSR) domain is required for sporozoite development and invasion. CSP has two conformational states, an adhesive conformation in which the TSP type-1 (TSR) domain is exposed and a nonadhesive conformation in which the TSR is masked by the N-terminus. TSR-exposed conformation occurs during sporozoite development in the oocyst in the mosquito vector and during host hepatocyte invasion. TSR-masked conformation occurs during sporozoite migration through the hemolymph to salivary glands in the mosquito vector and in the host dermis.

Sequence similarities

Belongs to the plasmodium circumsporozoite protein family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    505
  • Mass (Da)
    49,263
  • Last updated
    2017-02-15 v1
  • MD5 Checksum
    EF41900DA49B5075E046157FF3168CEB
MKKLAILSASSFLFADFLFQEYQHNGNYKNFRLLNEVCYNNMNIQLYNELEMENYMSNTYFYNNKKTIRLLGENDNEANVNRANNNVANDNRANGNRGNVNRANDRNIPYFRENVVNLNQPVGGNGGVQPAGGNGGVQPAGGNGGVQPAGGNGGVQPAGGNGGAQPVAAGGGAQPVVADGGVQPLRQEGDAEEDGGNGGVQPAGGNGGVQPAGGNGGVQPAGGNGGVQPAGGNGGVQPAGGNGGVQPAGGNGGVQPAGGNGGVQPAGGNGGVQPAGGNGGVQPAGGNGGVQPAGGNGGAQPAGGNGGAQPAGGNGGAQPAGGNGGAQPAGGNGGAQPAGGNGGAQPAGGNGGAQPAGGNGGAQPAGGNGGAQPAGGNGGAQPAGGNDAAKPDGGNDDDKPEGGDEKSEEEKEDEPIPDPTQEEIDKYLKSILGNVTSEWTNCNVTCGKGIQAKIKSTSANKKREEITPNDVEVKICELERCSFSIFNVISNSLGLAIILTFLFFY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias85-103Polar residues
Compositional bias391-406Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CVMV01000033
EMBL· GenBank· DDBJ
CRG95274.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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