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A0A1J0VJ03 · A0A1J0VJ03_9GAMM

  • Protein
    Urease subunit alpha
  • Gene
    ureC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

Ni cation (UniProtKB | Rhea| CHEBI:25516 )

Note: Binds 2 nickel ions per subunit.

Pathway

Nitrogen metabolism; urea degradation; CO2 and NH3 from urea (urease route): step 1/1.

Features

Showing features for binding site, active site.

156750100150200250300350400450500550
Type
IDPosition(s)Description
Binding site133Ni2+ 1 (UniProtKB | ChEBI)
Binding site135Ni2+ 1 (UniProtKB | ChEBI)
Binding site216Ni2+ 1 (UniProtKB | ChEBI); via carbamate group
Binding site216Ni2+ 2 (UniProtKB | ChEBI); via carbamate group
Binding site218substrate
Binding site245Ni2+ 2 (UniProtKB | ChEBI)
Binding site271Ni2+ 2 (UniProtKB | ChEBI)
Active site319Proton donor
Binding site359Ni2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionnickel cation binding
Molecular Functionurease activity
Biological Processurea catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Urease subunit alpha
  • EC number
  • Alternative names
    • Urea amidohydrolase subunit alpha

Gene names

    • Name
      ureC
    • ORF names
      BOX17_14275

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hb3
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Halomonadaceae > Halomonas

Accessions

  • Primary accession
    A0A1J0VJ03

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue216N6-carboxylysine

Post-translational modification

Carbamylation allows a single lysine to coordinate two nickel ions.
Carboxylation allows a single lysine to coordinate two nickel ions.

Interaction

Subunit

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain128-567Urease

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    567
  • Mass (Da)
    60,704
  • Last updated
    2017-02-15 v1
  • MD5 Checksum
    BF2CE80B2BF3FCE6C60EA144A77D749E
MKISRQAYADMYGPTLGDRVRLGDTDLWIEVEQDAAHYGDEVKFGGGKVIRDGMGQSQRHDDTVMDTVITNALILDWWGIVKADVGLKAGRIAAIGKAGNPDTQPDVTIVIGPGTEVIAGEGKILTAGGLDAHIHFICPQLVEEALMSGITTMLGGGTGPATGSNATTCTPGEWHIGKMLQAVDDLPMNIGLLGKGNASLPEALEAQLEAGAMGLKLHEDWGTTPAAIDNCLSVADRYDVQVAIHTDTLNESGFVEDTLAAFKERGIHTYHTEGAGGGHAPDILTACSKPYVLPSSTNPTRPYTVNTIDEHLDMLMVCHHLDPNIPEDVAFADSRIRRETIAAEDILQDLGVISMIASDSQAMGRVGEVVCRTWQTAHKMKQQRGLLPEDEARGADNVRARRYIAKYTINPAITHGIAHEVGSIEVGKLADLVLWKPAFFGTKPALILKGGMIAAAPMGDPNASIPTPQPVHYRPMFGAFGRAASQTRLTFVSQAALAAGVGERLGLRSPLSACRDVRGVRKSDMKLNDACPALSVDPQTYEVRCDGELLTCEPATELPLAQRYHLF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP018139
EMBL· GenBank· DDBJ
APE32016.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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