A0A1I9VT54 · A0A1I9VT54_9MONO

  • Protein
    Matrix protein VP40
  • Gene
    VP40
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Plays an essential role virus particle assembly and budding. Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendomembrane system
Cellular Componenthost cell endomembrane system
Cellular Componenthost cell late endosome membrane
Cellular Componenthost cell plasma membrane
Cellular Componentplasma membrane
Cellular Componentribonucleoprotein complex
Cellular Componentvirion membrane
Molecular FunctionRNA binding
Molecular Functionstructural constituent of virion
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processviral budding via host ESCRT complex
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Matrix protein VP40
  • Alternative names
    • Membrane-associated protein VP40

Gene names

    • Name
      VP40

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Reston virus/M.fascicularis-tc/USA/1989/Philippines89-AZ-1435
    • ITA_1992_
    • PHL_1992_
    • USA_PA_1989_
    • USA_VA_1989_
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Filoviridae > Orthoebolavirus > Orthoebolavirus restonense

Accessions

  • Primary accession
    A0A1I9VT54

Subcellular Location

Cell membrane
; Peripheral membrane protein
Endomembrane system
; Peripheral membrane protein
Endosome membrane
; Peripheral membrane protein
Host cell membrane
; Peripheral membrane protein
Host endomembrane system
; Peripheral membrane protein
Host late endosome membrane
; Peripheral membrane protein
Late endosome membrane
; Peripheral membrane protein
Membrane
; Peripheral membrane protein
Virion membrane
; Peripheral membrane protein
Note: In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and probably also in multivesicular bodies. These VP40-enriched membrane clusters are then redistributed to the plasma membrane where budding takes place.

Keywords

Structure

3D structure databases

Family & Domains

Sequence similarities

Belongs to the filoviridae matrix protein VP40 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    331
  • Mass (Da)
    35,821
  • Last updated
    2017-02-15 v1
  • Checksum
    921510B11D204799
MRRGVLPTAPPAYNDIAYPMSILPTRPSVIVNETKSDVLAVPGADVPSNSMRPVADDNIDHSSHTPSGVASAFILEATVNVISGTKVLMKQIPIWLPLGVADQKIYSFDSTTAAIMLASYTVTHFGKISNPLVRVNRLGPGIPDHPLRLLRLGNQAFLQEFVLPPVQLPQYFTFDLTALKLITQPLPAATWTDETPAGAVNALRPGLSLHPKLRPILLPGKTGKKGHASDLTSPDKIQTIMNAIPDLKIVPIDPTKNIVGIEVPELLVQRLTGKKPQPKNGQPIIPVLLPKYVGLDPISPGDLTMVITQDCDSCHSPASHPYHMDKQNSYQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY008770
EMBL· GenBank· DDBJ
APA16570.1
EMBL· GenBank· DDBJ
Viral cRNA
KY798004
EMBL· GenBank· DDBJ
ARU80298.1
EMBL· GenBank· DDBJ
Viral cRNA
KY798005
EMBL· GenBank· DDBJ
ARU80306.1
EMBL· GenBank· DDBJ
Viral cRNA
KY798006
EMBL· GenBank· DDBJ
ARU80314.1
EMBL· GenBank· DDBJ
Viral cRNA
KY798007
EMBL· GenBank· DDBJ
ARU80322.1
EMBL· GenBank· DDBJ
Viral cRNA
KY798008
EMBL· GenBank· DDBJ
ARU80330.1
EMBL· GenBank· DDBJ
Viral cRNA

Genome annotation databases

Similar Proteins

Disclaimer

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