A0A1I9VT54 · A0A1I9VT54_9MONO
- ProteinMatrix protein VP40
- GeneVP40
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids331 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Plays an essential role virus particle assembly and budding. Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endomembrane system | |
Cellular Component | host cell endomembrane system | |
Cellular Component | host cell late endosome membrane | |
Cellular Component | host cell plasma membrane | |
Cellular Component | plasma membrane | |
Cellular Component | ribonucleoprotein complex | |
Cellular Component | virion membrane | |
Molecular Function | RNA binding | |
Molecular Function | structural constituent of virion | |
Biological Process | symbiont-mediated suppression of host innate immune response | |
Biological Process | viral budding via host ESCRT complex | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMatrix protein VP40
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Filoviridae > Orthoebolavirus > Orthoebolavirus restonense
Accessions
- Primary accessionA0A1I9VT54
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Endomembrane system ; Peripheral membrane protein
Endosome membrane ; Peripheral membrane protein
Host cell membrane ; Peripheral membrane protein
Host endomembrane system ; Peripheral membrane protein
Host late endosome membrane ; Peripheral membrane protein
Late endosome membrane ; Peripheral membrane protein
Membrane ; Peripheral membrane protein
Virion membrane ; Peripheral membrane protein
Note: In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and probably also in multivesicular bodies. These VP40-enriched membrane clusters are then redistributed to the plasma membrane where budding takes place.
Keywords
- Cellular component
Sequence
- Sequence statusComplete
- Length331
- Mass (Da)35,821
- Last updated2017-02-15 v1
- Checksum921510B11D204799
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KY008770 EMBL· GenBank· DDBJ | APA16570.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KY798004 EMBL· GenBank· DDBJ | ARU80298.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KY798005 EMBL· GenBank· DDBJ | ARU80306.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KY798006 EMBL· GenBank· DDBJ | ARU80314.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KY798007 EMBL· GenBank· DDBJ | ARU80322.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KY798008 EMBL· GenBank· DDBJ | ARU80330.1 EMBL· GenBank· DDBJ | Viral cRNA |