A0A1I5MIP7 · A0A1I5MIP7_9PSED

Function

function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Ni2+ (UniProtKB | Rhea| CHEBI:49786 )

Note: Binds 1 nickel ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site56Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site74Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Active site122Proton donor/acceptor
Binding site122Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionlactoylglutathione lyase activity
Molecular Functionmetal ion binding
Biological Processmethylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lactoylglutathione lyase
  • EC number
  • Alternative names
    • Glyoxalase I

Gene names

    • Name
      gloA
    • ORF names
      CDR19_00975
      , SAMN05216177_101209

Organism names

  • Taxonomic identifier
  • Strains
    • DSM 26169
    • JCM 15604
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A1I5MIP7

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-126VOC

Sequence similarities

Belongs to the glyoxalase I family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    130
  • Mass (Da)
    14,579
  • Last updated
    2017-04-12 v1
  • Checksum
    69323D8559B3FA3F
MRLLHTMLRVGDLDQSIAFYTEVLGMTLLRRKDYPDGQFTLAFVGYGDEAHNSVIELTHNWGVDSYELGTGYGHIALEVEDVYKACEDIRSRGGKITREPGPMKHGSSILAFVEDPDGYKVELLSPKRSD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NIQV01000001
EMBL· GenBank· DDBJ
PIA74775.1
EMBL· GenBank· DDBJ
Genomic DNA
FOXK01000001
EMBL· GenBank· DDBJ
SFP09167.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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