A0A1I0R311 · A0A1I0R311_9FIRM

Function

function

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
Isomerase that catalyzes the conversion of deoxy-ribose 1-phosphate (dRib-1-P) and ribose 1-phosphate (Rib-1-P) to deoxy-ribose 5-phosphate (dRib-5-P) and ribose 5-phosphate (Rib-5-P), respectively.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions.

Pathway

Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 1/2.
Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site11Mn2+ 1 (UniProtKB | ChEBI)
Binding site291Mn2+ 2 (UniProtKB | ChEBI)
Binding site296Mn2+ 2 (UniProtKB | ChEBI)
Binding site332Mn2+ 1 (UniProtKB | ChEBI)
Binding site333Mn2+ 1 (UniProtKB | ChEBI)
Binding site344Mn2+ 2 (UniProtKB | ChEBI)
Active site489Proton donor/acceptor
Active site553Schiff-base intermediate with acetaldehyde
Active site582Proton donor/acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondeoxyribose-phosphate aldolase activity
Molecular Functionmagnesium ion binding
Molecular Functionmanganese ion binding
Molecular Functionphosphopentomutase activity
Biological Process2-deoxyribose 1-phosphate catabolic process
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processcellular metabolic compound salvage
Biological Processdeoxyribonucleotide catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Deoxyribose-phosphate aldolase
  • EC number
  • Short names
    DERA
  • Alternative names
    • 2-deoxy-D-ribose 5-phosphate aldolase
    • Phosphodeoxyriboaldolase
      (Deoxyriboaldolase
      )
  • Recommended name
    Phosphopentomutase
  • EC number
  • Alternative names
    • Phosphodeoxyribomutase

Gene names

    • Name
      deoC
    • Synonyms
      deoB
    • ORF names
      SAMN05216413_2295

Organism names

Accessions

  • Primary accession
    A0A1I0R311

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-378Metalloenzyme

Sequence similarities

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
Belongs to the phosphopentomutase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    610
  • Mass (Da)
    65,061
  • Last updated
    2017-11-22 v1
  • Checksum
    DD138DFC92E03617
MAKRVFIVVLDSFGIGLAPDAAAFGDEGSNTLAAVCSYSNDAFPNLARMGLWHIDGHDDSRITSWIDAQESLPSPIGSYGRIRELSAGKDSTIGHWEMAGVTSSKPLPTYPEGFPQEILDKLKKATGRDILCNKPYSGTDVIRDYGEEHMKTGALIVYTSADSVLQIAAHEDIVPVETLYEYCRSAREIMTGEHAVGRIIARPFTGEPGNFTRTPRRHDYSLEAPSATLNDVLKNEGLDVISVGKINDLFAGRGVTESNPTSGNTEGIAKLIEFMDRDFHGLCYVNLVDFDMKYGHRNDIEGYATAMHEFDDGLGKVLDLLNKDDLLIITADHGCDPSTESTDHSRECVPVLVYGEGHDVPHNLGYMAGFSHVANIAYDALLAPSFTKAYTPAANSHVPSKDNIMSYVDMTNLKVTATADDITALVEKAVAAGAASVCVQPCYVKHASDVAAGRIAICTVIGFPNGYQTTAVKKFEALDACDNGASEIDMVINQCFLKSGDINAVGAEIGVIADAVHSKGAILKVIIETCNLTKAEKTVLCHIVTVQGADFIKTSTGFGSAGATVEDVALMRKISGPNVRVKAAGGIRTVEAAEAMIEAGAERIGASGLG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FOIY01000005
EMBL· GenBank· DDBJ
SEW34642.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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