A0A1H8D7H7 · A0A1H8D7H7_9SPHI

Function

Catalytic activity

  • ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.
    EC:6.5.1.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site, site.

1964100200300400500600700800900
Type
IDPosition(s)Description
Binding site7Mg2+ 1 (UniProtKB | ChEBI)
Binding site34Mg2+ 1 (UniProtKB | ChEBI)
Active site106
Active site147Proton donor/acceptor
Binding site147Mg2+ 1 (UniProtKB | ChEBI)
Binding site149Mg2+ 1 (UniProtKB | ChEBI)
Site149Transition state stabilizer
Site218Important for catalytic activity
Binding site247Mg2+ 1 (UniProtKB | ChEBI)
Active site248Proton acceptor
Binding site248Mg2+ 1 (UniProtKB | ChEBI)
Site248Interaction with DNA substrate

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA ligase (ATP) activity
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Biological ProcessDNA recombination
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA ligase (ATP)
  • EC number
  • Alternative names
    • NHEJ DNA polymerase

Gene names

    • ORF names
      SAMN05192574_102242

Organism names

  • Taxonomic identifier
  • Strain
    • Gh-48
  • Taxonomic lineage
    Bacteria > Bacteroidota > Sphingobacteriia > Sphingobacteriales > Sphingobacteriaceae > Mucilaginibacter

Accessions

  • Primary accession
    A0A1H8D7H7

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain397-521ATP-dependent DNA ligase family profile

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    964
  • Mass (Da)
    109,578
  • Last updated
    2017-11-22 v1
  • MD5 Checksum
    4D0B138A11E0A2C21E71E363E788584D
MKIATYNINNINSRLDVLLRWLDEAKPDIVCLQELKCEQNKFPESKLKAAGYNAVWQGQKSWNGVAILAKSEIKELRNDLPGEDEEYTHSRYIEAFIDGIVIGCIYLPNGNPWPGPKFDYKLRWFKRLTDHAENLVNRELPVILIGDYNVMPTDLDTYKPEKYINNALFRPESKKAYKNLVDQGWTDAIRNLYPSERIYTFWDYMRGAYGRNAGLRLDHFLLNKKIAKRLSAAQVDKHVRGWEHASDHAPVWIELADPDHAEKSKKAITDTTANSPMPAIKPETKRSAAMQDVETILARAPKGKVPSKLQPMKATLVREPFNDPGWLYEIKWDGYRALAVIQDNQAELISRNSISFDQFRPIAEALGQWNVNAVIDGEIVVLGEDGKSDFSAIQNWQRRKDGQLVYNVFDILWLEGRDLRDLPLTERKAVLETILPTDETIRLSKAFNVDGIEFFHAAEKAGIEGIMAKKADSTYTAGDRSKEWLKVKVERRQEVVIGAFTRNAGTEKLFSALAIGVYEKGVLRYIGKVGTGWSEKKQKEMMSEFEPLITDICPFDVEPDVDEPSQFRPRRLGAKPFWLKPQLVCEVNIAEITSDGKVRQASFKGMRKDKDPKDVVLEVPADTTETVAKADEMLEQVRTEPNPTNAMNKDIQPEASFLDPEKDSQTVKVNGCPLTFNHLSKVYWPEDGITKRDMFNYYDQVAEYMMPYLKDRPMSLNRFPNGIHGPSFYQKNVKDKVPDCMATMPHTNDKGEAKEYLVATNKASLLWMASLGCIEINPWFSRVQSPDNPDFCIIDLDPDKQHFDQVISAALEVKKVLDAIGVKAYPKTSGSTGMHIYIPLGAKYTYDQSQMFAKIIVTLVHKQIPEFTSLERMIKNRGGKMYLDFLQNRPDATIAGVYSLRPKPGATVSMPLAWDEVKPGLTMRHFTIHNSIARLNETGDLFKGVLGEGIDLSKTIKKAQEIFR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FOCL01000002
EMBL· GenBank· DDBJ
SEN03273.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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