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A0A1H7H0Y9 · A0A1H7H0Y9_STIAU

Function

function

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Catalytic activity

  • Hydrolysis of proteins in presence of ATP.
    EC:3.4.21.53 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

1820100200300400500600700800
Type
IDPosition(s)Description
Binding site368-375ATP (UniProtKB | ChEBI)
Active site691
Active site734

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionsequence-specific DNA binding
Molecular Functionserine-type endopeptidase activity
Biological Processcellular response to heat
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lon protease
  • EC number
  • Alternative names
    • ATP-dependent protease La

Gene names

    • Name
      lon
    • ORF names
      SAMN05444354_101584

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 17044
  • Taxonomic lineage
    Bacteria > Myxococcota > Myxococcia > Myxococcales > Cystobacterineae > Archangiaceae > Stigmatella

Accessions

  • Primary accession
    A0A1H7H0Y9

Proteomes

Subcellular Location

Keywords

Expression

Induction

By heat shock.

Interaction

Subunit

Homohexamer. Organized in a ring with a central cavity.

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias.

Type
IDPosition(s)Description
Domain18-216Lon N-terminal
Coiled coil202-276
Domain604-785Lon proteolytic
Region791-820Disordered
Compositional bias799-820Polar residues

Sequence similarities

Belongs to the peptidase S16 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    820
  • Mass (Da)
    92,123
  • Last updated
    2017-04-12 v1
  • MD5 Checksum
    7CD1FAD1634C8AE26D5FF525BB3DF5FE
MFFGRDDKKDAQKRGLTVPLLPLRDIIVFPHMVVPLFVGREKSIAALKDAMAHKGPDDKAVILLAAQKKAKTNDPTPDDIFHFGTVGHVIQLLPLPDGTVKVLVEGVRRAKVRKFLTNDAFFMVEVEEVEEHTEKTVELEALVRSVHSVFEAFVKLNKRIPPEMLMQVASIDDPARLADTIVAHLSLKLNDKQALLETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEYYLNEQMQAIQKELGERDEFKNEIQEIEEKLKNKRMSKEATLKVKKELKKLRMMSPMSAEATVVRNYIDWIISLPWYDETQDRLDVTEAEQVLNEDHYGLKKPKERILEYLAVQQLVKKLKGPVLCFVGPPGVGKTSLARSIARATGRKFVRLSLGGVRDEAEIRGHRRTYIGAMPGKLIQSLKKAGSNNPVFLLDEIDKMSTDFRGDPSAALLEVLDPEQNHNFNDHYLDLDYDLSKVMFICTANTMHNIPGPLQDRMEVIRIAGYTEPEKLSIARRYLIPKEQEANGLADVKVDISNEALKTIIHRYTRESGVRSLEREIGGVFRKIARDVLKKGKRDIDVDRKLAMKFLGTPRFRYGVAESEDQVGIVTGLAWTEMGGEILTTEATIMPGKGKLIITGKLGEVMQESAQAAMSYVRSRAERFGIDRKVFENYDIHVHLPEGAIPKDGPSAGVTICTALVSALTRVTVRKDVAMTGEITLRGRVLPIGGLKEKTLAAHRAGIKTVLIPKANKKDLKDIPKKIRMALRIVPVEFVDDVLREALVLEKPEEFGRNGKSLGDNLKPTSQVVDAQPGSSSAPV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias799-820Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FOAP01000001
EMBL· GenBank· DDBJ
SEK43974.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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