A0A1H5RST8 · A0A1H5RST8_9RHOB

  • Protein
    Xanthine-guanine phosphoribosyltransferase
  • Gene
    gpt
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site51-525-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site106-1145-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site107Mg2+ (UniProtKB | ChEBI)
Binding site110guanine (UniProtKB | ChEBI)
Binding site110xanthine (UniProtKB | ChEBI)
Binding site110-114GMP (UniProtKB | ChEBI)
Binding site152-153GMP (UniProtKB | ChEBI)
Binding site153guanine (UniProtKB | ChEBI)
Binding site153xanthine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionxanthine phosphoribosyltransferase activity
Biological ProcessGMP salvage
Biological Processpurine ribonucleoside salvage
Biological ProcessXMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Xanthine-guanine phosphoribosyltransferase
  • EC number
  • Short names
    XGPRT
  • Alternative names
    • Xanthine phosphoribosyltransferase

Gene names

    • Name
      gpt
    • ORF names
      SAMN05421751_101144

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 23413
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Jhaorihella

Accessions

  • Primary accession
    A0A1H5RST8

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-163Phosphoribosyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    171
  • Mass (Da)
    19,159
  • Last updated
    2017-01-18 v1
  • MD5 Checksum
    52067314A74EA48152A1347B899AC0D0
MSDKDPNRLPHEKGFHVSWDQLHRDARALAWRLDGQGPDNGAWRAVVAITRGGMAPAMIVSRELDIRIVDTISVKSYHHQAQGEAQVLKAPDAQLMGDGEGVLVIDDLVDSGKTLELVRSMYPKAHFATIYAKPKGKPQVDSYITEVSQDTWIFFPWDMALQYVQPFRGSD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FNVD01000001
EMBL· GenBank· DDBJ
SEF41416.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help