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A0A1H4EKM4 · A0A1H4EKM4_9GAMM

  • Protein
    Bifunctional protein HldE
  • Gene
    hldE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.

Catalytic activity

Pathway

Bacterial outer membrane biogenesis; LPS core biosynthesis.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site195-198ATP (UniProtKB | ChEBI)
Active site264

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionheptose 7-phosphate kinase activity
Molecular Functionheptose-1-phosphate adenylyltransferase activity
Molecular Functionphosphotransferase activity, alcohol group as acceptor
Biological ProcessADP-L-glycero-beta-D-manno-heptose biosynthetic process
Biological Processlipopolysaccharide core region biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein HldE

Including 2 domains:

  • Recommended name
    D-beta-D-heptose 7-phosphate kinase
  • EC number
  • Alternative names
    • D-beta-D-heptose 7-phosphotransferase
    • D-glycero-beta-D-manno-heptose-7-phosphate kinase
  • Recommended name
    D-beta-D-heptose 1-phosphate adenylyltransferase
  • EC number
  • Alternative names
    • D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase

Gene names

    • Name
      hldE
    • ORF names
      SAMN05660964_02629

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 21228
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Thiotrichales > Thiotrichaceae > Thiothrix

Accessions

  • Primary accession
    A0A1H4EKM4

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-319Ribokinase
Domain11-306Carbohydrate kinase PfkB
Domain344-436Cytidyltransferase-like
Region344-478Cytidylyltransferase

Sequence similarities

In the C-terminal section; belongs to the cytidylyltransferase family.
In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    478
  • Mass (Da)
    51,412
  • Last updated
    2017-11-22 v1
  • MD5 Checksum
    7126A17696E375482F9FA39D0746875A
MSLQIPLFERARVLVVGDVMLDRYWSGQTSRISPEAPVPVVHVKANEERPGGAANVALNVASLGGQAVLLGYVGNDEAGRSLANTLQARGVQTHFVVLDTAPTITKLRVLSRHQQLIRLDFEEGFAGQDHAPLFSQFKALLAAADVVVLSDYRKGTLERARELIALAQAVGKPVVVDPKAQDFATYQGATVITPNLAEFREAVGEWVDEADLVQRGQALLARCELGNLLLTRSEQGMTLLRHEFAPYNLPTRAREVFDVTGAGDTVVAVLAAGMAAGLPLEQAMGLANLAAGIVVGKVGTATVSVPELHKALQQHHAQVKGVVSEAQLLAAVQEARIHGERIVMTNGCFDILHIGHVTYLEEARKLGDRLIVAVNTDESVRALKGPTRPVNTMANRMRMLAALACVDWVVDFSEYTPERLICAVKPDLLVKGGDNDPQKIPGNRCVWDNGGDVVVLSFVDGVSTTSTIARIQAMEKEA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FNQP01000016
EMBL· GenBank· DDBJ
SEA85601.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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