A0A1G7F9I7 · A0A1G7F9I7_9DEIN

  • Protein
    Shikimate dehydrogenase (NADP(+))
  • Gene
    aroE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site14-16shikimate (UniProtKB | ChEBI)
Binding site60shikimate (UniProtKB | ChEBI)
Active site64Proton acceptor
Binding site85shikimate (UniProtKB | ChEBI)
Binding site100shikimate (UniProtKB | ChEBI)
Binding site123-127NADP+ (UniProtKB | ChEBI)
Binding site146-151NADP+ (UniProtKB | ChEBI)
Binding site205NADP+ (UniProtKB | ChEBI)
Binding site207shikimate (UniProtKB | ChEBI)
Binding site228NADP+ (UniProtKB | ChEBI)
Binding site235shikimate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • ORF names
      SAMN04488243_10830

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CGMCC 1.6992
  • Taxonomic lineage
    Bacteria > Deinococcota > Deinococci > Thermales > Thermaceae > Thermus

Accessions

  • Primary accession
    A0A1G7F9I7

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-86Shikimate dehydrogenase substrate binding N-terminal
Domain119-171Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Domain228-258SDH C-terminal

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    263
  • Mass (Da)
    28,133
  • Last updated
    2017-11-22 v1
  • Checksum
    FA36C94EF697D5E9
MLRFAVLGHPVAHSLSPAMHAFALESLGLEGRYEAWETPLEALPGRLKEVRRAFRGVNLTLPLKEAALAHLDWASPEAQRIGAVNTALQVEGRLFGFNTDAPGFLEALKAGGIPLKGPALVLGAGGAGRAVAFALKEAGLEVWVWNRTPKRALALAEEFGLRAVPLEKAKEARLLVNATSVGLGDPGATPLPPELLPEEGAAVDLVYRPLWTRFLREAKERGLKVQTGLPMLAWQGALAFRIWTGLLPDPSGMEEAALRALGV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FNBC01000008
EMBL· GenBank· DDBJ
SDE72623.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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