A0A1G7F9I7 · A0A1G7F9I7_9DEIN
- ProteinShikimate dehydrogenase (NADP(+))
- GenearoE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids263 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Catalytic activity
- shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 14-16 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: SLS | ||||||
Binding site | 60 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Active site | 64 | Proton acceptor | ||||
Sequence: K | ||||||
Binding site | 85 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 100 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 123-127 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GAGGA | ||||||
Binding site | 146-151 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: NRTPKR | ||||||
Binding site | 205 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 207 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 228 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 235 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | NADP binding | |
Molecular Function | shikimate 3-dehydrogenase (NADP+) activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process | |
Biological Process | shikimate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate dehydrogenase (NADP(+))
- EC number
- Short namesSDH
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Deinococcota > Deinococci > Thermales > Thermaceae > Thermus
Accessions
- Primary accessionA0A1G7F9I7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-86 | Shikimate dehydrogenase substrate binding N-terminal | ||||
Sequence: VLGHPVAHSLSPAMHAFALESLGLEGRYEAWETPLEALPGRLKEVRRAFRGVNLTLPLKEAALAHLDWASPEAQRIGAVNT | ||||||
Domain | 119-171 | Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase | ||||
Sequence: ALVLGAGGAGRAVAFALKEAGLEVWVWNRTPKRALALAEEFGLRAVPLEKAKE | ||||||
Domain | 228-258 | SDH C-terminal | ||||
Sequence: GLPMLAWQGALAFRIWTGLLPDPSGMEEAAL |
Sequence similarities
Belongs to the shikimate dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length263
- Mass (Da)28,133
- Last updated2017-11-22 v1
- ChecksumFA36C94EF697D5E9