A0A1G6KSK3 · A0A1G6KSK3_NIADE
- ProteinDihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids417 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO2.
Catalytic activity
- N6-[(R)-dihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = N6-[(R)-S8-succinyldihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA
Cofactor
Note: Binds 1 lipoyl cofactor covalently.
Pathway
Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | oxoglutarate dehydrogenase complex | |
Molecular Function | dihydrolipoyllysine-residue succinyltransferase activity | |
Biological Process | L-lysine catabolic process to acetyl-CoA via saccharopine | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Chitinophagia > Chitinophagales > Chitinophagaceae > Niabella
Accessions
- Primary accessionA0A1G6KSK3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 2-76 | Lipoyl-binding | |||
Region | 79-121 | Disordered | |||
Compositional bias | 90-106 | Basic and acidic residues | |||
Domain | 123-160 | Peripheral subunit-binding (PSBD) | |||
Sequence similarities
Belongs to the 2-oxoacid dehydrogenase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length417
- Mass (Da)44,733
- Last updated2017-11-22 v1
- MD5 Checksum93D8CEAA3AAE5152F58D1A28603CAF36
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 90-106 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FMZO01000002 EMBL· GenBank· DDBJ | SDC34050.1 EMBL· GenBank· DDBJ | Genomic DNA |