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A0A1G6KSK3 · A0A1G6KSK3_NIADE

Function

function

E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO2.

Catalytic activity

Cofactor

(R)-lipoate (UniProtKB | Rhea| CHEBI:83088 )

Note: Binds 1 lipoyl cofactor covalently.

Pathway

Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentoxoglutarate dehydrogenase complex
Molecular Functiondihydrolipoyllysine-residue succinyltransferase activity
Biological ProcessL-lysine catabolic process to acetyl-CoA via saccharopine
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
  • EC number
  • Alternative names
    • 2-oxoglutarate dehydrogenase complex component E2

Gene names

    • ORF names
      SAMN04487894_10289

Organism names

Accessions

  • Primary accession
    A0A1G6KSK3

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain2-76Lipoyl-binding
Region79-121Disordered
Compositional bias90-106Basic and acidic residues
Domain123-160Peripheral subunit-binding (PSBD)

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    417
  • Mass (Da)
    44,733
  • Last updated
    2017-11-22 v1
  • MD5 Checksum
    93D8CEAA3AAE5152F58D1A28603CAF36
MAIDIKVPTVGESISEVTLLKWVKNTGEYVERDEVIAELESEKATFEVNAEKAGVLTTNVAEGDTLNIGDTIASIDDTAAKPEAAPEQAPTDKVPDEAKKPAPDPEKAKPAATPGNAGAPAVKATPVASAIIADKGVNPKDVTPSGFSGKIVKEDVLAALANPGRKAFVAGGELYSRNERAQKMTSLRKTISRRLVEAKNTTAMLTTFNEVNMKPIMDIRAKYKDKFKEAHGVGLGFMSFFAKACAVALAEWPSVNAYIDGDQILFHDYADISIAVSTPRGLTVPVIRNVESLSMAGVEKAVLDLAKKARDSKLTAEDLTGGTFTITNGGVFGSLISTPIINLPQSAILGMHNIVERPIAENGQVVIRPMMYIALSYDHRIVDGRESVSFLVRVKELLENPTLLLIQQDPIKTLLEL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias90-106Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FMZO01000002
EMBL· GenBank· DDBJ
SDC34050.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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