A0A1G5W956 · A0A1G5W956_9EURY
- ProteinBifunctional enzyme Fae/Hps
- Genefae-hps
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids411 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H4MPT) to 5,10-methylenetetrahydromethanopterin.
Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
Catalytic activity
- 5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O
Pathway
Carbohydrate biosynthesis; D-ribose 5-phosphate biosynthesis.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 20 | Proton donor | |||
Binding site | 22 | substrate | |||
Binding site | 69 | substrate | |||
Binding site | 71 | substrate | |||
Binding site | 86 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-dehydro-L-gulonate-6-phosphate decarboxylase activity | |
Molecular Function | carbon-nitrogen lyase activity | |
Molecular Function | hexulose-6-phosphate synthase activity | |
Molecular Function | hydro-lyase activity | |
Molecular Function | orotidine-5'-phosphate decarboxylase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | carbohydrate biosynthetic process | |
Biological Process | L-ascorbic acid catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional enzyme Fae/Hps
Including 2 domains:
- Recommended name5,6,7,8-tetrahydromethanopterin hydro-lyase
- EC number
- Alternative names
- Recommended name3-hexulose-6-phosphate synthase
- EC number
- Short namesHPS
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales > Methanobacteriaceae > Methanobrevibacter
Accessions
- Primary accessionA0A1G5W956
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-164 | Formaldehyde-activating enzyme | |||
Region | 165-411 | 3-hexulose-6-phosphate synthase | |||
Domain | 177-389 | Orotidine 5'-phosphate decarboxylase | |||
Sequence similarities
In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
In the N-terminal section; belongs to the formaldehyde-activating enzyme family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length411
- Mass (Da)44,892
- Last updated2017-01-18 v1
- MD5 Checksum4A61B39347FA2D8B5C50DD87CFF49166
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FMXB01000008 EMBL· GenBank· DDBJ | SDA54542.1 EMBL· GenBank· DDBJ | Genomic DNA |