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A0A1G5W956 · A0A1G5W956_9EURY

Function

function

Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H4MPT) to 5,10-methylenetetrahydromethanopterin.
Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Carbohydrate biosynthesis; D-ribose 5-phosphate biosynthesis.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site20Proton donor
Binding site22substrate
Binding site69substrate
Binding site71substrate
Binding site86substrate

GO annotations

AspectTerm
Molecular Function3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Molecular Functioncarbon-nitrogen lyase activity
Molecular Functionhexulose-6-phosphate synthase activity
Molecular Functionhydro-lyase activity
Molecular Functionorotidine-5'-phosphate decarboxylase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processcarbohydrate biosynthetic process
Biological ProcessL-ascorbic acid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional enzyme Fae/Hps

Including 2 domains:

  • Recommended name
    5,6,7,8-tetrahydromethanopterin hydro-lyase
  • EC number
  • Alternative names
    • Formaldehyde-activating enzyme
      (Fae
      )
  • Recommended name
    3-hexulose-6-phosphate synthase
  • EC number
  • Short names
    HPS
  • Alternative names
    • D-arabino-3-hexulose-6-phosphate formaldehyde lyase

Gene names

    • Name
      fae-hps
    • ORF names
      SAMN02910315_01259

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 16643
  • Taxonomic lineage
    Archaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales > Methanobacteriaceae > Methanobrevibacter

Accessions

  • Primary accession
    A0A1G5W956

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-164Formaldehyde-activating enzyme
Region165-4113-hexulose-6-phosphate synthase
Domain177-389Orotidine 5'-phosphate decarboxylase

Sequence similarities

In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    411
  • Mass (Da)
    44,892
  • Last updated
    2017-01-18 v1
  • MD5 Checksum
    4A61B39347FA2D8B5C50DD87CFF49166
MDPMYRIGEALIGDGPELAHIDLLIGDKFGPVGQAFANGLSNLSIGHTPLTSVIRPNLMTKPATLIIPKVTVGDLSDASKIFGPAQTAVARAVADAVEDGYIPKDIVEDIVINVSVFIDPSAEDFRKIYQYNYGATKLAIRRAMEGYPSIEKVLAEKDRGTHPIMGFRVQKLWSPPYLQVALDLDSKEAMARILNDIPDKERVLIEAGTPLVKKFGVGVVEDIRALRPSAFIIADLKTLDVGRVEIKMAADATADAVAISGLGTIESIKKAIHETQKQGIYAILDMMNVKDFEAKLSQLPDDLKPDIVLLHRNVDLETYKAEKGEDISEMTEWGNIKKIKEIIGDGLIAVAGGITPENVEEAIDKGADIIIAGRYIIGSRDVRRSAQDFLAHFPPDPDNMRLAMDEDEQVN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FMXB01000008
EMBL· GenBank· DDBJ
SDA54542.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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