A0A1G3C1Q0 · A0A1G3C1Q0_9BACT
- ProteinATP-dependent Clp protease proteolytic subunit
- GeneclpP
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids197 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Catalytic activity
- Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 98 | Nucleophile | |||
Active site | 123 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | endopeptidase Clp complex | |
Cellular Component | membrane | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | ATPase binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | protein quality control for misfolded or incompletely synthesized proteins |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent Clp protease proteolytic subunit
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageBacteria > Planctomycetota
Accessions
- Primary accessionA0A1G3C1Q0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 88-107 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
Structure
Sequence
- Sequence statusComplete
- Length197
- Mass (Da)22,190
- Last updated2017-02-15 v1
- ChecksumA19BB54D8CBB5B49
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MHZA01000163 EMBL· GenBank· DDBJ | OHC01407.1 EMBL· GenBank· DDBJ | Genomic DNA |