A0A1G1KK10 · A0A1G1KK10_9BACT

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site73substrate
Binding site201-203substrate
Binding site210Mn2+ (UniProtKB | ChEBI)
Binding site230Mn2+ (UniProtKB | ChEBI)
Binding site252substrate
Binding site253-258GTP (UniProtKB | ChEBI)
Active site254
Binding site277Mn2+ (UniProtKB | ChEBI)
Binding site372-374substrate
Binding site374GTP (UniProtKB | ChEBI)
Binding site498-501GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      A3K16_06290

Organism names

Accessions

  • Primary accession
    A0A1G1KK10

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-220Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain226-586Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    588
  • Mass (Da)
    66,270
  • Last updated
    2017-02-15 v1
  • Checksum
    93CC8018489CB0E2
MATSLERWVDEQAALTKPKSIYWCDGSEAEAHKLIEIGIREERINGQPIFHELNQKVWPNAYLHRSHPTDVARTEHLTYVCYPDKETAGPNNNWMDPEEAKAMMRKLFDGCMTGKTMYVLPYMMGSADSPYAKACVQLTDVSYVAISMRIMTRVGKFAIEKISKDGDFVKGLHSIGDLDPNKRFIMHFPLEHLVWSVGSGYGGNALLGKKCFSLRIASWLGLKEGWLAEHMVIMGIQDPEGEITYITAAMPSACGKTNLAMMESALPGYKIWTLGDDIAWMNIGPDGRLWAINPEAGFFGVAPGTSAKTNPNMLRTLKKNGFYPTLFTNTALNTDTNEPWWEGMDGAAPKNLADWQGNKWSGSLGRQAAHPNSRFTVSIYNAPTLSKEADNPKGVPISAMIFGGKRTALIPLVYESLNWQNGVFSAARMGSETTAAAVHQVGVLRRDPMAMLPFCGYNMGDYFKHWINLGKNMPKPPKIFCVNWFRQDKLGNFIWPGFGENIRVLKWIIDRAKGKVKGRETPIGVVPKSEDMNLHGLNIDKQNLEKLFEVKLDDWKQEIEDVRKFLEQFGDRMPKEMWEEYNALKNNY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MHFN01000075
EMBL· GenBank· DDBJ
OGW93211.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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