A0A1F4AZU7 · A0A1F4AZU7_9PROT

Function

function

Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mo-molybdopterin (UniProtKB | Rhea| CHEBI:71302 )

Note: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site78Mo-molybdopterin (UniProtKB | ChEBI)
Binding site81-82Mo-molybdopterin (UniProtKB | ChEBI)
Binding site135Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI)
Binding site170Mo-molybdopterin (UniProtKB | ChEBI)
Binding site218Mo-molybdopterin (UniProtKB | ChEBI)
Binding site223Mo-molybdopterin (UniProtKB | ChEBI)
Binding site234-236Mo-molybdopterin (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functionmolybdopterin cofactor binding
Molecular Functionoxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor
Biological Processprotein repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein-methionine-sulfoxide reductase catalytic subunit MsrP
  • EC number

Gene names

    • Name
      msrP
    • ORF names
      A3I01_11345

Organism names

Accessions

  • Primary accession
    A0A1F4AZU7

Proteomes

PTM/Processing

Post-translational modification

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Interaction

Subunit

Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain97-250Oxidoreductase molybdopterin-binding

Sequence similarities

Belongs to the MsrP family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    315
  • Mass (Da)
    36,242
  • Last updated
    2017-02-15 v1
  • MD5 Checksum
    13F0E7E59DB9DBEB335DE5515F373D1C
MLIKRPNDIQPSQITPCDIYRRRREFIKAAAVVALGAVSGVLPHQAQAQQGTKLGGIAKSRSSTNEKANSLKDISSYNNYYEFGTDKDDPVVHAKRLKTRPWTVVVEGEVRKPRTFGVEELLKFPLEERIYRLRCVEAWSMVIPWVGFEFNRIAKLVEPTGKAKFVEFVSAYQPENMVGVRLPVLEWPYLEGLRIDEAMHPLTIMALGLYDEMLPNQNGAPIRVVVPWKYGFKSGKSIVRIRFVEKQPRIAWEKANPQEYGFYSNVNPNVDHPRWSQKREKRLPAFFANRDTQLFNGYGDQVAQLYAGMDLKKFY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MERA01000360
EMBL· GenBank· DDBJ
OGA17539.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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