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A0A1F0EV33 · A0A1F0EV33_9FIRM

Function

function

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site97-99substrate
Binding site121-124substrate; in site B
Binding site131-133substrate
Binding site179substrate
Active site180Proton donor/acceptor
Active site310
Binding site311substrate
Binding site316-318substrate
Site323Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionfumarate hydratase activity
Biological Processfumarate metabolic process
Biological Processmalate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumarate hydratase class II
  • EC number
  • Short names
    Fumarase C
  • Alternative names
    • Aerobic fumarase
    • Iron-independent fumarase

Gene names

    • Name
      fumC
    • ORF names
      HMPREF3045_05570

Organism names

  • Taxonomic identifier
  • Strain
    • HMSC075B03
  • Taxonomic lineage
    Bacteria > Bacillota > Tissierellia > Tissierellales > Peptoniphilaceae > Anaerococcus

Accessions

  • Primary accession
    A0A1F0EV33

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain, coiled coil.

Type
IDPosition(s)Description
Domain13-333Fumarate lyase N-terminal
Coiled coil146-176
Domain400-452Fumarase C C-terminal

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    452
  • Mass (Da)
    50,812
  • Last updated
    2017-02-15 v1
  • MD5 Checksum
    9F3C98DA61A3CC12BFC1785E40E2480A
MKYRQEEDSLGIVNVPANHFWGAQTERSLENFPQEVEKMPHSQIMAIASIKRCAAIVNNKEKKLDDNKKDLIVKACDRILKGEFDNEFPLTVWQTGSGTQTNMNVNEVISHIANENEKIIHPNDHVNMSQSSNDVFPTAMHLSTYKNLSEKLLKELEKTIDAIKKLEDENKNIIKTGRTHLQDATPLKLSQEISAWRTCLERDLKVLKEVKEELTYLAIGGTAVGTGINAKKEFGNEMAKELSDFYGFEFKSDENKFYQLSSKSALVNVHGTIKALATDLYKIANDIRFLSCGPRCGISELTIPANEPGSSIMPGKVNPTQVESITMVCIKIMANDFAISMANTQGQLQLNTYMPLIIHSMDNSITLLSKSLKCFREKLLEGLVANEKNIAKNLENSLMLVTSLSPHIGYDKASKIAKYAYKNNLTLKQACHELEYLSDEEFDEIVKPEKMV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LTSR01000093
EMBL· GenBank· DDBJ
OFO40251.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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