Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A1E8RAF8 · A0A1E8RAF8_9FIRM

Function

function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site86
Active site362Nucleophile

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionL-methionine:thioredoxin-disulfide S-oxidoreductase activity
Molecular Functionpeptide-methionine (R)-S-oxide reductase activity
Molecular Functionpeptide-methionine (S)-S-oxide reductase activity
Biological Processprotein modification process
Biological Processprotein repair
Biological Processresponse to oxidative stress

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Peptide methionine sulfoxide reductase MsrA
  • EC number
  • Short names
    Protein-methionine-S-oxide reductase
  • Alternative names
    • Peptide-methionine (S)-S-oxide reductase
      (Peptide Met(O) reductase
      )
  • Recommended name
    Peptide methionine sulfoxide reductase MsrB
  • EC number
  • Alternative names
    • Peptide-methionine (R)-S-oxide reductase

Gene names

    • Name
      msrA
    • Synonyms
      msrB
    • ORF names
      HMPREF2852_01730

Organism names

  • Taxonomic identifier
  • Strain
    • HMSC065G05
  • Taxonomic lineage
    Bacteria > Bacillota > Tissierellia > Tissierellales > Peptoniphilaceae > Anaerococcus

Accessions

  • Primary accession
    A0A1E8RAF8

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_503861044721-389Multifunctional fusion protein

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain250-373MsrB

Sequence similarities

Belongs to the MsrA Met sulfoxide reductase family.
Belongs to the MsrB Met sulfoxide reductase family.
In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.
In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    389
  • Mass (Da)
    44,561
  • Last updated
    2017-02-15 v1
  • MD5 Checksum
    C45D9E1C37CB02A338F20197BC5F17E6
MKSKFIFVFLICAIFLVACSNKSKNKSKDNGNISSTNEEIGKKIDEIIDSNNKKNLKEMENQKNMDKEKENYSKDDLKKIYLAGGCFWGVEEYMQRIYGVYDAVSGYANGKVNNPTYKTVSSGKSGYAETVEVTYDSKKIKLEDLLNHYFKIIDPTSLNKQGNDRGSQYRTGIYYVDDSDKEVIDKVMNFQAKKYSEKIVVENMKLKNFIVAEDYHQDYLRKNPNGYCHIDLSKAGEVVIDPAKYPKPSDDDLKRKLTDIQYRVTQKNETESSFSNEYWDNKEKGIYVDVATGEPLFSSSDKFDSGCGWPSFSKPIAKDVVTYREDKSYNMNRTEVRSRSGDSHLGHVFNDGPKELGGLRFCINSASIKFIPLKDMEDRGYGYLKHLVK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LTEJ01000095
EMBL· GenBank· DDBJ
OFJ67618.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help