A0A1E8Q5M2 · A0A1E8Q5M2_9MYCO
- ProteinMultifunctional 2-oxoglutarate metabolism enzyme
- Genekgd
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1279 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- N6-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H+ = N6-[(R)-S8-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2
Cofactor
Protein has several cofactor binding sites:
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from 2-oxoglutarate (transferase route): step 1/2.
Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | oxoglutarate dehydrogenase complex | |
Molecular Function | 2-hydroxy-3-oxoadipate synthase activity | |
Molecular Function | 2-oxoglutarate decarboxylase activity | |
Molecular Function | dihydrolipoyllysine-residue succinyltransferase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | oxoglutarate dehydrogenase (succinyl-transferring) activity | |
Molecular Function | thiamine pyrophosphate binding | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultifunctional 2-oxoglutarate metabolism enzyme
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium
Accessions
- Primary accessionA0A1E8Q5M2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 27-156 | Disordered | |||
Compositional bias | 30-53 | Polar residues | |||
Compositional bias | 68-86 | Polar residues | |||
Compositional bias | 98-116 | Basic and acidic residues | |||
Coiled coil | 838-865 | ||||
Domain | 928-1127 | Transketolase-like pyrimidine-binding | |||
Sequence similarities
Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,279
- Mass (Da)139,784
- Last updated2017-02-15 v1
- Checksum0332DCACC27911D2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 30-53 | Polar residues | |||
Compositional bias | 68-86 | Polar residues | |||
Compositional bias | 98-116 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MCHX01000019 EMBL· GenBank· DDBJ | OFJ53863.1 EMBL· GenBank· DDBJ | Genomic DNA |