A0A1E8Q5M2 · A0A1E8Q5M2_9MYCO

  • Protein
    Multifunctional 2-oxoglutarate metabolism enzyme
  • Gene
    kgd
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from 2-oxoglutarate (transferase route): step 1/2.
Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentoxoglutarate dehydrogenase complex
Molecular Function2-hydroxy-3-oxoadipate synthase activity
Molecular Function2-oxoglutarate decarboxylase activity
Molecular Functiondihydrolipoyllysine-residue succinyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionoxoglutarate dehydrogenase (succinyl-transferring) activity
Molecular Functionthiamine pyrophosphate binding
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional 2-oxoglutarate metabolism enzyme
  • EC number
  • Alternative names
    • 2-hydroxy-3-oxoadipate synthase
    • 2-oxoglutarate carboxy-lyase
    • 2-oxoglutarate decarboxylase
    • Alpha-ketoglutarate decarboxylase
    • Alpha-ketoglutarate-glyoxylate carboligase

Gene names

    • Name
      kgd
    • ORF names
      BEL07_10010

Organism names

  • Taxonomic identifier
  • Strain
    • SCH
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium

Accessions

  • Primary accession
    A0A1E8Q5M2

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for region, compositional bias, coiled coil, domain.

Type
IDPosition(s)Description
Region27-156Disordered
Compositional bias30-53Polar residues
Compositional bias68-86Polar residues
Compositional bias98-116Basic and acidic residues
Coiled coil838-865
Domain928-1127Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,279
  • Mass (Da)
    139,784
  • Last updated
    2017-02-15 v1
  • Checksum
    0332DCACC27911D2
MYRKFREDPSSVDPSWHEFLVDYAPEPANDTSAVTANGTANGSRSSSANGKGEPKTPPTPAPAPPPGSNGASSASKPASKSAATSASAPAAKPAEPKPAAKSEAKPAAKPEAKPAAKSEAKPAAPATKPATSSTAANPEPAKPKAPAAAAAEDDQTQVLRGAAAAVAKNMSASLEVPTATSVRAIPAKLMIDNRVVINNHLKRTRGGKISFTHLLGYAIVQAVKNFPNMNRHFAEVDGKPNVVTPAHTNLGLAIDLPGKDGNRSLVVAAIKKADTMRFGQFIAAYEDIVRRARDGKLTAEDFAGVTISLTNPGTIGTVHSVPRLMRGQGAIIGAGAMEYPAEFQGASEERINEVGVGKLMTLTSTYDHRIIQGAESGDFLRTIHQLLLSDDFFDEIFRELGIPYEPVRWRTDNPDAITDKNARIIELIAAYRNRGHLMADIDPLRLDKTRFRSHPDLDVNTHGLTLWDLDREFKVDGFAGAQYKKLRDVLSVLRDAYCRHVGVEYTHILEPEQQRWIQERVEAKHEKPTVAEQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAETVIPMMDAAIDQAAEHGLDEVVIGMPHRGRLNVLANIVGKPYSQIFSEFEGNLNPSQAHGSGDVKYHLGAGGTYLQMFGDNDIEVSLVANPSHLEAVDPVLEGIVRAKQDVIDKGNGPDGFTVVPLMMHGDAAFAGQGVVAETLNLALLRGYRTGGTIHIVVNNQIGFTTSPVNSRSSEYCTDVAKMIGAPIFHVNGDDPEAAAWVARLAVDFRQKFKKDVVIDMLCYRRRGHNEGDDPSMTQPYMYDVIDTKRGVRKTYTEALIGRGDISMKEAEDALRDYQGQLERVFNEVRELEKHDIEPSESVESDQVTPQGLSTAVDKSLLARIGDAHLSFPDDFTVHPRVKPVLEKRREMAYEGKVDWAFGELLALGTLVSEGKLVRLSGQDTRRGTFTQRHSVIIDRKTGAEFTPLQLLATNTDGTPSGGKFMVYDSALSEYAAVGFEYGYSVGNPDAMVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSDVVLLLPHGHEGQGPDHTSGRIERFLQVCAEGSMTVAMPSTPANYFHLLRRHGLDGIHRPLIVFTPKSMLRNKAAVSDIRDFTEQKFRSILEEPTYTDGDGDRSKVKRVLLTSGKIYYELAARKAKEKREDVAIVRVEQLYPLPKRRLAATLDEYPNAEQFCWVQEEPANQGAWPTFGLTMPESLPDKLTGIKRISRRAMSAPSSGSSKVHAVEQQEIIDEAFA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias30-53Polar residues
Compositional bias68-86Polar residues
Compositional bias98-116Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MCHX01000019
EMBL· GenBank· DDBJ
OFJ53863.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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