A0A1E8Q2C3 · A0A1E8Q2C3_9MYCO

Function

function

NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site20-40NAD+ (UniProtKB | ChEBI)
Binding site96-99NAD+ (UniProtKB | ChEBI)
Active site114Proton acceptor
Binding site122Zn2+ (UniProtKB | ChEBI)
Binding site125Zn2+ (UniProtKB | ChEBI)
Binding site176Zn2+ (UniProtKB | ChEBI)
Binding site179Zn2+ (UniProtKB | ChEBI)
Binding site216-218NAD+ (UniProtKB | ChEBI)
Binding site242-244NAD+ (UniProtKB | ChEBI)
Binding site260NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent protein lysine deacetylase activity
Molecular Functiontransferase activity
Molecular Functionzinc ion binding
Biological Processprotein deacetylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacetylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog

Gene names

    • Name
      cobB
    • ORF names
      BEL07_16425

Organism names

  • Taxonomic identifier
  • Strain
    • SCH
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium

Accessions

  • Primary accession
    A0A1E8Q2C3

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-274Deacetylase sirtuin-type

Sequence similarities

Belongs to the sirtuin family. Class II subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    276
  • Mass (Da)
    29,159
  • Last updated
    2017-02-15 v1
  • Checksum
    32ED8DEC37B90444
MEGPELLRVLAGQRVAVLTGAGMSTDSGIPDYRGPDSPPANPMTIRQFTSDATFRQRYWARNHVGWRHMAATLPNAGHRALAALERAGVVTGVITQNVDLLHTKAGSRNVVDLHGTYARVVCLTCDFAMSRADLADQLEALNPGFLERAERLGGIAVAPDADATVDDTASFRFLDCPQCGGMLKPDIVYFGESVPKPRVAQAYSIVDDADALLVAGSSLTVFSGLRFVRHAAAAGKPIAILNRGATRGDALATVKVHGGCSELLALLADELALPTG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MCHX01000036
EMBL· GenBank· DDBJ
OFJ52682.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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