A0A1E8Q2C3 · A0A1E8Q2C3_9MYCO
- ProteinNAD-dependent protein deacetylase
- GenecobB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids276 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Catalytic activity
- N6-acetyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 20-40 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 96-99 | NAD+ (UniProtKB | ChEBI) | |||
Active site | 114 | Proton acceptor | |||
Binding site | 122 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 125 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 176 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 179 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 216-218 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 242-244 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 260 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | NAD+ binding | |
Molecular Function | NAD-dependent protein lysine deacetylase activity | |
Molecular Function | transferase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protein deacetylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD-dependent protein deacetylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium
Accessions
- Primary accessionA0A1E8Q2C3
Proteomes
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length276
- Mass (Da)29,159
- Last updated2017-02-15 v1
- Checksum32ED8DEC37B90444
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MCHX01000036 EMBL· GenBank· DDBJ | OFJ52682.1 EMBL· GenBank· DDBJ | Genomic DNA |