A0A1E7U509 · A0A1E7U509_9BURK

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site7-12substrate
Binding site39Mg2+ (UniProtKB | ChEBI)
Active site68Proton acceptor
Binding site68Mg2+ (UniProtKB | ChEBI)
Binding site69substrate
Binding site154-157substrate
Binding site177substrate
Binding site182-183substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      CKY39_27180
      , J2W25_003984

Organism names

  • Taxonomic identifier
  • Strains
    • J1
    • DS2795
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Variovorax

Accessions

  • Primary accession
    A0A1E7U509

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    199
  • Mass (Da)
    21,104
  • Last updated
    2017-01-18 v1
  • Checksum
    7E8F8F859463EC4A
MKLVLASNNAGKLAELQQLFAELSVTLVPQSALGVGEAEEPFRTFVENALTKARHASAATGLPAIADDAGLCVDAFGGLPGVDTAYYATQFGYAKGDANNVKALLEQLDGVVNRRAALVSTLVALRRHDDPEPLIAVGRVVGEIAPAPIGDNGFGFDPVMYLPTFGKTFAQLPPDVKNANSHRGRAAQAMLALMRERWF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP023284
EMBL· GenBank· DDBJ
ATA56510.1
EMBL· GenBank· DDBJ
Genomic DNA
JAUSRR010000006
EMBL· GenBank· DDBJ
MDP9924948.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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