A0A1E7TXD8 · A0A1E7TXD8_9BURK

  • Protein
    Peptidoglycan D,D-transpeptidase MrdA
  • Gene
    mrdA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes cross-linking of the peptidoglycan cell wall.

Catalytic activity

  • Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
    EC:3.4.16.4 (UniProtKB | ENZYME | Rhea)

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

166550100150200250300350400450500550600650
TypeIDPosition(s)Description
Active site329Acyl-ester intermediate

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionpenicillin binding
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peptidoglycan D,D-transpeptidase MrdA
  • EC number
  • Alternative names
    • Penicillin-binding protein 2
      (PBP-2
      )

Gene names

    • Name
      mrdA
    • ORF names
      CKY39_01665
      , J2W26_000940

Organism names

  • Taxonomic identifier
  • Strains
    • J1
    • DS2796
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Variovorax

Accessions

  • Primary accession
    A0A1E7TXD8

Proteomes

Subcellular Location

Cell inner membrane
; Single-pass membrane protein
Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-38Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain62-237Penicillin-binding protein dimerisation
Domain270-608Penicillin-binding protein transpeptidase

Sequence similarities

Belongs to the transpeptidase family. MrdA subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    665
  • Mass (Da)
    72,309
  • Last updated
    2017-01-18 v1
  • Checksum
    4E54DCE4FFC043C3
MTEIRNVAADLARFKRRVIVIGLAVLFAFSLLGSRLVYLQVVRHADLAEQAESNRTAVVPVVPNRGLILDRNGIVLASNYSAYTLEITPSKVGDVEETINSLTSVLEVSPRDRRRFKRLREDSRSFDSIPIRTRLSDEEVARFAAQRYRFPGVEIKARLFRNYPQGELASHVLGYIGRINQREKTAMEDWDEEDQANYKGTDYIGKLGIEQSYEKMLHGQTGVEQMETSAGGRAVRRLASHPATPGNTVMLSLDIKLQKLVEDMYGDRRGALVAIDPKTGEVLAFVSKPTFDPNLFVEGIDTESWQALTESIDKPLLNRALRGTYPPGSTYKPFMALAALQTGKRAASVVVNDPGYFNFGGHRFGSPEGYLGGVDMRRSIQVSSNIYYYSLANEMGVDLIHDFMKPMGFGQITGIDLGGEVRGVLPSTEWKRNAYKRPEQKKWYAGETISLGIGQGYNAFTMLQLAQATAIVADGGMKHRPHLALAMRNTVSGQVVPLPQPPAENLGYTAANVAVIREGLTSVVTSGTARGVFAGAGYQAAGKTGTAQAVTQAKNTKYNARALEEHQRDHALFMAYAPANNPKIALAVIVENAGWGAGAAAPLARRVFDYWLMDQYPSEADMAAVRIGRAGAPMGKPRVASEVAWPAAAAVPAPAGAASSAAPTP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP023284
EMBL· GenBank· DDBJ
ATA52075.1
EMBL· GenBank· DDBJ
Genomic DNA
JAUSRS010000002
EMBL· GenBank· DDBJ
MDP9876641.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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