A0A1E7G8F9 · A0A1E7G8F9_9EURY
- ProteinImidazole glycerol phosphate synthase subunit HisF
- GenehisF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids273 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
Catalytic activity
- 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H+
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 11 | ||||
Active site | 134 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | imidazoleglycerol-phosphate synthase activity | |
Molecular Function | lyase activity | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameImidazole glycerol phosphate synthase subunit HisF
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Methanobacteriati > Methanobacteriota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanosarcina
Accessions
- Primary accessionA0A1E7G8F9
Proteomes
Subcellular Location
Interaction
Subunit
Heterodimer of HisH and HisF.
Structure
Sequence
- Sequence statusComplete
- Length273
- Mass (Da)29,814
- Last updated2017-01-18 v1
- MD5 ChecksumDD52385957234EE8118248FF286B036B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MDTP02000198 EMBL· GenBank· DDBJ | OEU41254.1 EMBL· GenBank· DDBJ | Genomic DNA |