A0A1E5LFQ0 · A0A1E5LFQ0_9BACI

  • Protein
    L-lactate dehydrogenase
  • Gene
    ldh
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of lactate to pyruvate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Allosterically activated by fructose 1,6-bisphosphate (FBP).

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site12-17NAD+ (UniProtKB | ChEBI)
Binding site16NAD+ (UniProtKB | ChEBI)
Binding site37NAD+ (UniProtKB | ChEBI)
Binding site42NAD+ (UniProtKB | ChEBI)
Binding site68NAD+ (UniProtKB | ChEBI)
Binding site82-83NAD+ (UniProtKB | ChEBI)
Binding site85substrate
Binding site91substrate
Binding site98NAD+ (UniProtKB | ChEBI)
Binding site104NAD+ (UniProtKB | ChEBI)
Binding site121-123NAD+ (UniProtKB | ChEBI)
Binding site123-126substrate
Binding site146NAD+ (UniProtKB | ChEBI)
Binding site151-154substrate
Binding site156beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Binding site171beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Active site178Proton acceptor
Binding site232substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionL-lactate dehydrogenase activity
Biological Processglycolytic process
Biological Processlactate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-lactate dehydrogenase
  • EC number
  • Short names
    L-LDH

Gene names

    • Name
      ldh
    • ORF names
      BFG57_14615

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • GH2-4
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus

Accessions

  • Primary accession
    A0A1E5LFQ0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue223Phosphotyrosine

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-145Lactate/malate dehydrogenase N-terminal
Domain148-313Lactate/malate dehydrogenase C-terminal

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    315
  • Mass (Da)
    34,733
  • Last updated
    2017-01-18 v1
  • Checksum
    CFDCE04F0DCE3836
MNNRVNRVALIGTGFVGSSYAFALLNQGIVEELVLIDANEEKACGDAMDLNHGLAFAPSSMKIWSGTYEDCKDADLVVITAGANQKPGETRLDLVEKNAAIFKTIVTSVMESGFDGIFLVATNPVDIMTYATWKYSGLPKERVIGSGTILDTARLRFLTGQYFEIDTRNVHAYVIGEHGDTELPVWSLAKVGGRSVCELVEENEQYKNEDLDDIFVNVRDAAYHIINRKGATYYGIAMGMVRLTKAVLNNENSILTVSAYLEGEYGQNDVYVGVPAVVNRNGLREVIEINLNEKEKEQFKHSAEVLKKTMAPIFG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MJEH01000021
EMBL· GenBank· DDBJ
OEH92904.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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