A0A1E4SU68 · A0A1E4SU68_9ASCO
- ProteinFatty acid synthase subunit beta
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2061 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
Catalytic activity
- (9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H+ + holo-[ACP]
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 277 | For acetyltransferase activity | ||||
Sequence: S | ||||||
Active site | 1818 | For malonyltransferase activity | ||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | fatty acid synthase complex | |
Molecular Function | (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity | |
Molecular Function | [acyl-carrier-protein] S-acetyltransferase activity | |
Molecular Function | [acyl-carrier-protein] S-malonyltransferase activity | |
Molecular Function | enoyl-[acyl-carrier-protein] reductase (NADH) activity | |
Molecular Function | fatty acid synthase activity | |
Molecular Function | fatty acyl-[ACP] hydrolase activity | |
Molecular Function | fatty-acyl-CoA synthase activity | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFatty acid synthase subunit beta
- EC number
Including 5 domains:
- Recommended name3-hydroxyacyl-[acyl-carrier-protein] dehydratase
- EC number
- Recommended nameEnoyl-[acyl-carrier-protein] reductase [NADH]
- EC number
- Recommended name[Acyl-carrier-protein] acetyltransferase
- EC number
- Recommended name[Acyl-carrier-protein] malonyltransferase
- EC number
- Recommended nameS-acyl fatty acid synthase thioesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Pichiaceae > Ogataea > Ogataea/Candida clade
Accessions
- Primary accessionA0A1E4SU68
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
[Alpha6beta6] hexamers of two multifunctional subunits (alpha and beta).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1674-2028 | Malonyl-CoA:ACP transacylase (MAT) | ||||
Sequence: VFTGQGSQEQGMGMDLYNSSEVAKAVWDRADVHFVENYGFSILEIVKNNPNELTVHFGGPKGRKIRESYKTMMFETVDADGKLKSEKIFKEIDDTTSTYTFKSPTGLLSATQFTQPALTLMEKAAFEDMKAKGLVPAESMFAGHSLGEYSALSSLADVMPIESLVDVVFYRGMTMQVAVPRDALGRSNYGMCAVNPSRISPTFTDAALRFVIDHISKQTGWLLEIVNYNVENQQYVTAGDLRGLDTLTNTLNVFKLQKIDIVKLQEMLSLEKVAEHLTEIVAEVSKKSLAKPQPIDLERGFACIPLKGISVPFHSSYLRSGVKPFQRFLVKKIPKSAVKPASLIGKYIPNLTAKP |
Sequence similarities
Belongs to the fungal fatty acid synthetase subunit beta family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,061
- Mass (Da)228,039
- Last updated2017-01-18 v1
- Checksum9E299D39503F12CC
Keywords
- Technical term