A0A1E3SII9 · A0A1E3SII9_MYCIE

Function

function

APS kinase catalyzes the synthesis of activated sulfate.
Catalyzes the synthesis of activated sulfate.
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.
Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site14-21GTP (UniProtKB | ChEBI)
Binding site91-95GTP (UniProtKB | ChEBI)
Binding site146-149GTP (UniProtKB | ChEBI)
Binding site453-460ATP (UniProtKB | ChEBI)
Active site527Phosphoserine intermediate

GO annotations

AspectTerm
Molecular Functionadenylylsulfate kinase activity
Molecular FunctionATP binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionsulfate adenylyltransferase (ATP) activity
Biological Processhydrogen sulfide biosynthetic process
Biological Processsulfate assimilation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Sulfate adenylyltransferase subunit 1
  • EC number
  • Alternative names
    • ATP-sulfurylase large subunit
    • Sulfate adenylate transferase
      (SAT
      )
  • Recommended name
    Adenylyl-sulfate kinase
  • EC number
  • Alternative names
    • APS kinase
    • ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
    • Adenosine-5'-phosphosulfate kinase

Gene names

    • Name
      cysC
    • Synonyms
      cysN
    • ORF names
      BHQ20_09380
      , BST27_09600

Organism names

  • Taxonomic identifier
  • Strains
    • HMC2_M5
    • DSM 44049
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium simiae complex

Accessions

  • Primary accession
    A0A1E3SII9

Proteomes

PTM/Processing

Keywords

Interaction

Subunit

Heterodimer composed of CysD, the smaller subunit, and CysN.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-220Tr-type G

Sequence similarities

Belongs to the APS kinase family.
In the C-terminal section; belongs to the APS kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    617
  • Mass (Da)
    67,970
  • Last updated
    2017-01-18 v1
  • Checksum
    70BD3B1F7AF48446
MAAPTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQLAAVERTSKERGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIRHLVLAVNKMDLIDWDKEKFEAIRDEFHAFAARLDVQDVTSIPLSALHGDNVVTKSDQTPWYEGPSLLSHLEEVYIGGDRNLVDVRFPVQYVIRPHTLDHQDHRSYAGTVASGVMRPGDEVVVLPVGKTTRITAIDGPTGPVEEAFPPMAVSISLADDIDISRGDMIARANNQPRIAQSFDATVCWMADDSALEPGRDYIIKHTTRTTRARITALDYRLDVNTLHRDKTAAALKLNELGRVSLRTQSPLLLDEYTRNATTGSFILIDPDTNGTVAAGMILRDVSTHTASPNTVRHKSLVTAEDRATKGKTLWLTGLSGAGKSSVAMLVEQKLLERGIPAYVLDGDNLRHGLNADLGFSMADRAENLRRLAHVATLLADSGQIVLVPAISPLAEHREMARKVHVDAGFPFFEVFCDTPIEECERRDPKGLYAKARAGEITHFTGIDSPYQRPKNPDLRLTVDHTLEEQAQAVLDLIESFS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MIHB01000011
EMBL· GenBank· DDBJ
ODR01378.1
EMBL· GenBank· DDBJ
Genomic DNA
MVHT01000019
EMBL· GenBank· DDBJ
ORB07488.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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