A0A1E3LHG6 · A0A1E3LHG6_9BURK
- ProteinKynurenine formamidase
- GenekynB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids205 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
Catalytic activity
- N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H+
Cofactor
Note: Binds 2 zinc ions per subunit.
Pathway
Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 15 | substrate | |||
Binding site | 45 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 49 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 51 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 51 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Active site | 55 | Proton donor/acceptor | |||
Binding site | 157 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 169 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 169 | Zn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | arylformamidase activity | |
Molecular Function | formamidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | tryptophan catabolic process to kynurenine |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKynurenine formamidase
- EC number
- Short namesKFA ; KFase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Pandoraea
Accessions
- Primary accessionA0A1E3LHG6
Proteomes
Interaction
Structure
Sequence
- Sequence statusComplete
- Length205
- Mass (Da)22,168
- Last updated2017-01-18 v1
- ChecksumCF0786F4301E87C4
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MAOS01000037 EMBL· GenBank· DDBJ | ODP33206.1 EMBL· GenBank· DDBJ | Genomic DNA |