A0A1E3LHG6 · A0A1E3LHG6_9BURK

  • Protein
    Kynurenine formamidase
  • Gene
    kynB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 zinc ions per subunit.

Pathway

Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site15substrate
Binding site45Zn2+ 1 (UniProtKB | ChEBI)
Binding site49Zn2+ 1 (UniProtKB | ChEBI)
Binding site51Zn2+ 1 (UniProtKB | ChEBI)
Binding site51Zn2+ 2 (UniProtKB | ChEBI)
Active site55Proton donor/acceptor
Binding site157Zn2+ 2 (UniProtKB | ChEBI)
Binding site169Zn2+ 1 (UniProtKB | ChEBI)
Binding site169Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionarylformamidase activity
Molecular Functionformamidase activity
Molecular Functionzinc ion binding
Biological Processtryptophan catabolic process to kynurenine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Kynurenine formamidase
  • EC number
  • Short names
    KFA
    ; KFase
  • Alternative names
    • Arylformamidase
    • N-formylkynurenine formamidase
      (FKF
      )

Gene names

    • Name
      kynB
    • ORF names
      A9762_20380

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ISTKB
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Pandoraea

Accessions

  • Primary accession
    A0A1E3LHG6

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the Cyclase 1 superfamily. KynB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    205
  • Mass (Da)
    22,168
  • Last updated
    2017-01-18 v1
  • Checksum
    CF0786F4301E87C4
MWDISAPLSASTPVWPGDTPFAEEAVWQIGPGCPVNVGRITLSPHTGAHADAPRHYDDAGAFIGEVDLQTYLGPCRVIHCIGASPVVTPEMVEAHLKDVPPRVLLRTYAHAPVAQWDSAFCAVAPETIDLLASHGVKLVGIDTPSLDPQESKTMDAHHRIRAHRMAILEGLVLDAIEPADYELIALPLKFMRLDASPVRAVLRSL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MAOS01000037
EMBL· GenBank· DDBJ
ODP33206.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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