A0A1E3HBN9 · A0A1E3HBN9_9TREE
- ProteinUbiquinone biosynthesis monooxygenase COQ6, mitochondrial
- GeneCOQ6
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids596 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
Catalytic activity
- 4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
Cofactor
Pathway
Cofactor biosynthesis; ubiquinone biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extrinsic component of mitochondrial inner membrane | |
Molecular Function | 2-octaprenyl-6-methoxyphenol hydroxylase activity | |
Molecular Function | 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity | |
Molecular Function | FAD binding | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
Biological Process | ubiquinone biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquinone biosynthesis monooxygenase COQ6, mitochondrial
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus
Accessions
- Primary accessionA0A1E3HBN9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 74-334 | FAD-binding | ||||
Sequence: YDIVIIGGANAGLALACALLSQPTLSTTTRVLLLEGASLDKTRTWPQSEEWENRVSSLTHESVEWLESIGVWKHIVEERSRPVYEIVIWSNPSADSNPTIHFPPIGRPLARMTENLNLQQALLKRINEIGEGIVDIRENSRVGEMRLGEGGRWVGLRIGDEWVKGSLVVGADGPNSPVRHFSEIDSYGHAYNTHAVVATMHHTASSFYPNNTGFQRFLPTGPIAFLPLSETTSTLVWSTRPENAAALKKLSPEGLTAMINA | ||||||
Domain | 395-451 | FAD-binding | ||||
Sequence: SIASFPLRLSHATSYLGARTALVGDAAHTIHPLAGQGLNMGLADVRSLAETLEASKK | ||||||
Region | 525-550 | Disordered | ||||
Sequence: PFSTGGRSEKEREFGRSEAGESMKSA |
Sequence similarities
Belongs to the UbiH/COQ6 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length596
- Mass (Da)64,334
- Last updated2017-01-18 v1
- Checksum92429F47E309069E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AWGJ01000013 EMBL· GenBank· DDBJ | ODN73196.1 EMBL· GenBank· DDBJ | Genomic DNA |