A0A1E3H8X6 · A0A1E3H8X6_9TREE
- ProteinMultifunctional tryptophan biosynthesis protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids765 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.
Catalytic activity
- 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+ = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
Pathway
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 86 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 176 | |||||
Sequence: H | ||||||
Active site | 178 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | anthranilate synthase activity | |
Molecular Function | indole-3-glycerol-phosphate synthase activity | |
Molecular Function | phosphoribosylanthranilate isomerase activity | |
Biological Process | glutamine metabolic process | |
Biological Process | tryptophan biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultifunctional tryptophan biosynthesis protein
Including 3 domains:
- Recommended nameAnthranilate synthase component 2
- EC number
- Short namesAS
- Alternative names
- Recommended nameIndole-3-glycerol phosphate synthase
- EC number
- Short namesIGPS
- Recommended nameN-(5'-phosphoribosyl)anthranilate isomerase
- EC number
- Short namesPRAI
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus
Accessions
- Primary accessionA0A1E3H8X6
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-193 | Glutamine amidotransferase | ||||
Sequence: LLIDNYDSFTWNIYADIAAIGGNPYVVRNDKITLQEIQKLYETDQIARIVISPGPGHPRTDSGVSRDVIQWGMGKLPIMGVCMGLECLVDCLGGDIGYAGEIMHGKSSFVTHDSIGCFHDLPQDLSSIRYHSLAASISTIPQCLQVTSTSKESGVIMGVRHRVYTVEAVQYHPESCLSEGGKGLMANFL | ||||||
Domain | 240-503 | Indole-3-glycerol phosphate synthase | ||||
Sequence: LNKIHSQRLQDIDQAKTILSTTPDNVSKSIALHTAPPLISFYDRVKNTPHTAIMAEIKRASPSKGDIAPDASAPEQGLKYALAGASVISVLTEPKWFKGSLIDMLAVRNAVSTLPNRPAILRKDFVLSTYMIDEARLYGADTVLLIVAMLDPDLLSTLYNYSVSLGMEPLVEVNNPTELELALQIGSKVIGVNNRNLHDFNVDMSTTTRVNAALKGRGDVILCALSGISQPEDVETYVKEGVKAVLVGESLMRAKDTGAFLRSL | ||||||
Domain | 583-761 | N-(5'phosphoribosyl) anthranilate isomerase (PRAI) | ||||
Sequence: PSSSPEPWFRHNLTTLSSRPKPLLVGVFQNQPLASVIHQTTAIELDLVQLHGDEPQQWAQFIPVPVIKVFRVDDEGKVRGGEVARPGQNSFILLDKGTAQGGGGEGLSFPWKVAKSLISAGEANSLAHPLPVILAGGLTPENVGTAIEETGNGVWCVDVSSGVEGEGGKDEAKVRAFVK |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length765
- Mass (Da)81,838
- Last updated2017-01-18 v1
- Checksum21096BD46047DFD4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AWGJ01000014 EMBL· GenBank· DDBJ | ODN72744.1 EMBL· GenBank· DDBJ | Genomic DNA |