Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A1E3H1A0 · A0A1E3H1A0_9HYPH

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

methylcob(III)alamin (UniProtKB | Rhea| CHEBI:28115 )

Features

Showing features for binding site.

1844100200300400500600700800
TypeIDPosition(s)Description
Binding site296methylcob(III)alamin (UniProtKB | ChEBI)
Binding site363-367methylcob(III)alamin (UniProtKB | ChEBI)
Binding site366Co (UniProtKB | ChEBI) of methylcob(III)alamin (UniProtKB | ChEBI); axial binding residue
Binding site411methylcob(III)alamin (UniProtKB | ChEBI)
Binding site415methylcob(III)alamin (UniProtKB | ChEBI)
Binding site468methylcob(III)alamin (UniProtKB | ChEBI)
Binding site554S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site743S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site798-799S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalamin binding
Molecular Functionmethionine synthase activity
Molecular Functionzinc ion binding
Biological Processhomocysteine metabolic process
Biological Processmethylation
Biological Processtetrahydrofolate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methionine synthase
  • EC number

Gene names

    • Name
      metH_2
    • ORF names
      A6302_02612

Organism names

  • Taxonomic identifier
  • Strain
    • PK2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Pleomorphomonadaceae > Methylobrevis

Accessions

  • Primary accession
    A0A1E3H1A0

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-216Pterin-binding
Domain252-346B12-binding N-terminal
Domain353-489B12-binding
Domain504-836AdoMet activation

Sequence similarities

Belongs to the vitamin-B12 dependent methionine synthase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    844
  • Mass (Da)
    92,771
  • Last updated
    2017-01-18 v1
  • MD5 Checksum
    A5A6F5E2B1C9DA4BD4DD1AA94A593E16
MDEGLLDSEGAMIEFLNLIASEPDIARVPVMIDSSKWSIIEEGLKRVQGKPIVNSISLKEGEEAFIHHARLVRRYGAAVVVMAFDEKGQADTLARKTEICKRSYDILTQTVGFPPEDIIFDPNIFAVATGIEEHDNYGVDFIEATGWIMNHLPHAHVSGGVSNLSFSFRGNEPVREAMHSVFLYHAIAKGMDFGIVNAGQLAVYDDIDPVLRELCEDVVLNRKPAPGALSATERLVEEAPRFKGDGAKQRVVDLSWREWPVEKRLEHALVSGITEYIEADTEEARLTVARPLHVIEGPLMAGMNVVGDLFGSGKMFLPQVVKSARVMKQAVAWLMPFMEQEKRDMGLTDRPAAGKIVMATVKGDVHDIGKNIVGVVLQCNNYEVIDLGVMVPFQKILDTAKAVNADIIGLSGLITPSLDEMCVVAAEMERQGFDVPLLIGGATTSRVHTAVKIHPNYARGQAVYVTDASRAVGVVSTLLGDKRDGYIADTRAEYVKLAEAHARGQADKRRLPLASARAKAPKYDFASVPPKAPSFIGTKAFDDYDIGEIARYIDWTPFFSTWEMKGAYPAILEDEHYGPAARALFEDAQAMLKQMIDEKWLTARAVIGLWPANAVGDDIEVYADESRTTPIARFHGLRQQIARDSARANMSISDFVAPKATGVADYVGGFAVTAGIGEDVVAERFARANDDYSKILSQALADRLAEAFAEHMHQRVRKEFWGYVADEDLTPQALIAEEYVGIRPAAGYPAQPDHTEKRTLFDLLDAEAATGITLTESFAMWPAAAVSGLYFSHPESHYFGVGKIERDQVEDYAARKGMSVAETERWLAPILNYDPARILEAAAE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MCRJ01000063
EMBL· GenBank· DDBJ
ODN70072.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help