A0A1E2UV46 · A0A1E2UV46_9GAMM

Function

function

Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions.
    EC:3.1.26.12 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per homotetramer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site299Mg2+ (UniProtKB | ChEBI); catalytic
Binding site342Mg2+ (UniProtKB | ChEBI); catalytic
Binding site400Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site403Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoplasmic side of plasma membrane
Molecular Functionmagnesium ion binding
Molecular Functionribonuclease E activity
Molecular FunctionRNA endonuclease activity
Molecular FunctionrRNA binding
Molecular FunctiontRNA binding
Molecular Functionzinc ion binding
Biological ProcessmRNA catabolic process
Biological ProcessrRNA processing
Biological ProcesstRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease E
  • EC number
  • Short names
    RNase E

Gene names

    • Name
      rne
    • ORF names
      A3196_13695

Organism names

Accessions

  • Primary accession
    A0A1E2UV46

Proteomes

Subcellular Location

Cytoplasm
Cell inner membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain36-117S1 motif
Region400-403Required for zinc-mediated homotetramerization and catalytic activity
Region518-556Disordered
Region571-1001Disordered
Compositional bias586-600Polar residues
Compositional bias613-650Basic and acidic residues
Compositional bias692-713Polar residues
Compositional bias714-728Basic and acidic residues
Compositional bias744-790Basic and acidic residues
Compositional bias792-817Polar residues
Compositional bias820-841Basic and acidic residues
Compositional bias855-870Basic and acidic residues
Compositional bias970-986Polar residues

Sequence similarities

Belongs to the RNase E/G family. RNase E subfamily.
Belongs to the RNase E/G family. RNase G subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,001
  • Mass (Da)
    110,202
  • Last updated
    2017-01-18 v1
  • Checksum
    E9C4340C2073376A
MLINATQPEELRVAIVDGQKLFNLDIEIPGREQKKANIYKGRITRVEPSLEAAFVDYGAERHGFLPLKEISRSYFTNKARESSGRVNIQEALKEGQEVIVQVEKEERGNKGAALTTFISLAGRYLVLMPNNPRAGGVSRRIEGQDRTELREAMSELQIPEDMGLIVRTAGVGKNSEELQWDLDYLIQLWTAIEHSAEKPAPFLIYQESNVIIRSIRDYLRADIGEIVIDDADVYGQAERFINQVMPQYSKKLRHYDDEVPLFSRYQIESQIESAFQREVSLPSGGAIVIDHTEALTSIDINSARATKGADIEETALNTNLEAADEVARQLRLRDLGGLFVIDFIDMTPSRNQREVENRLKEALKQDRARVQIGRISRFGLLEMSRQRLRPSLGEASEQACPRCKGHGTVRGVESLSLSVLRIIEEEAMKENTGRIMAQLPVDMATFLLNEKRQMIHDIEKRQSIEVVLIPNIHLETPNYQIDRIRASDLPDEDDTVSSYKMVSDETTETAEYITAKQVKSEQPAVKSIAPASPAPQRAEAPAPTPAPAATDSQTGETGFLKKIFSIFSSKEAEPVQPEAEEKKAPARQQSGSNSNNRRGRRAAQPGGRNVKSAGGERRGDNRNQDKPSNRRRGGNKAGGSADKRATQEKKPQEQAAPATAAAAGDNTETTTKPKSRRGRRGGRRRRSAAERNNEQTTVNNGATEATSEAPAQEKSQEKSQEKPKRQQPRAQKKPASPRAAKVETSTEAKQETESRDDNSRVEAKQKPQQVDRVAERAEAGPKEKPKAKPQPEQQAKSAQSEPATAKPVESQASSESKPEAGLKPAKKRETTTAESKPSEQKAKPAKPAGQVETTKAKTEIKEKPAETKATQTSARKEPVENAVKPKPKPKPKPKAVKLQQVETKPIAQESKAESAKVEKPKTNATAETQIAKAEAKATPESQAAKPEARATPRPQAAKPEARATIEKAQESRAQPASKTVQVETKKPAANTDVKVADASGD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias586-600Polar residues
Compositional bias613-650Basic and acidic residues
Compositional bias692-713Polar residues
Compositional bias714-728Basic and acidic residues
Compositional bias744-790Basic and acidic residues
Compositional bias792-817Polar residues
Compositional bias820-841Basic and acidic residues
Compositional bias855-870Basic and acidic residues
Compositional bias970-986Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LVJZ01000003
EMBL· GenBank· DDBJ
ODB98637.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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