A0A1E1XUR8 · A0A1E1XUR8_AMBSC
- ProteinShort-chain specific acyl-CoA dehydrogenase, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids391 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.
Catalytic activity
- hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
- pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H+ = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]This reaction proceeds in the forward direction.
Cofactor
Pathway
Lipid metabolism; mitochondrial fatty acid beta-oxidation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | acyl-CoA dehydrogenase activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Biological Process | butyrate catabolic process | |
Biological Process | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShort-chain specific acyl-CoA dehydrogenase, mitochondrial
- EC number
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Parasitiformes > Ixodida > Ixodoidea > Ixodidae > Amblyomminae > Amblyomma
Accessions
- Primary accessionA0A1E1XUR8
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 14-125 | Acyl-CoA dehydrogenase/oxidase N-terminal | |||
Domain | 129-224 | Acyl-CoA oxidase/dehydrogenase middle | |||
Domain | 236-384 | Acyl-CoA dehydrogenase/oxidase C-terminal | |||
Sequence similarities
Belongs to the acyl-CoA dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length391
- Mass (Da)42,521
- Last updated2017-01-18 v1
- ChecksumEA6E6F8039D88CED
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GFAA01000412 EMBL· GenBank· DDBJ | JAU03023.1 EMBL· GenBank· DDBJ | mRNA |