A0A1E1XUR8 · A0A1E1XUR8_AMBSC

  • Protein
    Short-chain specific acyl-CoA dehydrogenase, mitochondrial
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Pathway

Lipid metabolism; mitochondrial fatty acid beta-oxidation.

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functionacyl-CoA dehydrogenase activity
Molecular Functionflavin adenine dinucleotide binding
Biological Processbutyrate catabolic process
Biological Processfatty acid beta-oxidation using acyl-CoA dehydrogenase

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Short-chain specific acyl-CoA dehydrogenase, mitochondrial
  • EC number
  • Alternative names
    • Butyryl-CoA dehydrogenase

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Parasitiformes > Ixodida > Ixodoidea > Ixodidae > Amblyomminae > Amblyomma

Accessions

  • Primary accession
    A0A1E1XUR8

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-125Acyl-CoA dehydrogenase/oxidase N-terminal
Domain129-224Acyl-CoA oxidase/dehydrogenase middle
Domain236-384Acyl-CoA dehydrogenase/oxidase C-terminal

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    391
  • Mass (Da)
    42,521
  • Last updated
    2017-01-18 v1
  • Checksum
    EA6E6F8039D88CED
RWQCVRNLFVQLPETHEMLRKTCREFAEKELKPIAGTFDKEHQYPREQIRKLGEMGLMAVAVPQELGGAGLDYLAYAIGMEEISRGCASTGVVMSVNNSLYLGGILKFGTEEQKQKFIPPFTTGEKVGCFALSEPGNGSDAGAASTTAVLEGDHYRLNGTKAWITSAYEGEAAIVMATIDKSKKHKGINAFIVPMPSPGLSLGKKEDKLGIRGSSTAQLIFEDCLVPKENRLGEDGAGFKIAMSVLDSGRIGIAGQALGIGQAALECALEYSGKRESFNQPLHKFQAIQMKLADMEVRLQSARLLTWRAAMLKDAGLKFTKEAAMAKLAASETATFVAHQALQILGGMGYVTDMPAERHYRDARITEIYEGTSEVQRIVIASNLLKEHGIV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GFAA01000412
EMBL· GenBank· DDBJ
JAU03023.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help