A0A1E1UVI7 · A0A1E1UVI7_9HYPH

  • Protein
    3-methyl-2-oxobutanoate hydroxymethyltransferase
  • Gene
    panB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site51Mg2+ (UniProtKB | ChEBI)
Binding site51-523-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site903-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site90Mg2+ (UniProtKB | ChEBI)
Binding site1193-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site121Mg2+ (UniProtKB | ChEBI)
Active site188Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionmethyltransferase activity
Biological Processmethylation
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-methyl-2-oxobutanoate hydroxymethyltransferase
  • EC number
  • Alternative names
    • Ketopantoate hydroxymethyltransferase
      (KPHMT
      )

Gene names

    • Name
      panB
    • ORF names
      BIWAKO_00187

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BIWAKO-01
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Boseaceae > Bosea

Accessions

  • Primary accession
    A0A1E1UVI7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodecamer; pentamer of dimers.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the PanB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    271
  • Mass (Da)
    28,643
  • Last updated
    2017-01-18 v1
  • Checksum
    BB724B20856D98CB
MAYLSDARTLTLADFARMKTAGEKVAMMTCYDSSFASLLESCGVEILLIGDSMGNVLQGHATTLPVTMEQMVYHTACVARGARRAFIMADMPFGSYQEGPAQAMHNAARLMAAGAHMVKLEGSDYAVEAVRFLVERGVPVCGHLGLTPQSVHQLGGYRVQGKSADAATKLKADAAALEQAGARFLVLEMVPSTLAAEIGETSDAMLTIGIGAGVHCNGQVLVLHDAIGVYPGKRPRFSKDFMVGAGSIPEAIQAYVAAVKSQEFPGPEHSY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BCQA01000001
EMBL· GenBank· DDBJ
GAU80301.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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