A0A1D9P546 · A0A1D9P546_9FIRM

  • Protein
    Hypoxanthine phosphoribosyltransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleotide binding
Biological ProcessGMP salvage
Biological Processguanine salvage
Biological Processhypoxanthine metabolic process
Biological ProcessIMP salvage
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hypoxanthine phosphoribosyltransferase
  • EC number

Gene names

    • ORF names
      bhn_I2704

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MB2003
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Butyrivibrio

Accessions

  • Primary accession
    A0A1D9P546

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-158Phosphoribosyltransferase

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    174
  • Mass (Da)
    19,592
  • Last updated
    2017-02-15 v1
  • Checksum
    A9CFBE1A524A9E65
MAESVRVLLTEEEVDKRIKELGEAISRDYQGETVHLVCVLKGGVFFMCELAKRITIPVTMDFMSASSYGSSTKSSGVVKIVKDLDEPLKDRHVIVVEDIVDSGRTLSYLLKMLGDRGPASIKLCTLLDKPERRVTDVKVDYTGFEIPDEFVVGYGLDYDQRYRNLPYIGVVEFN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP017831
EMBL· GenBank· DDBJ
AOZ97736.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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