A0A1D9P4H0 · A0A1D9P4H0_9FIRM

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site7-12substrate
Binding site40Mg2+ (UniProtKB | ChEBI)
Active site78Proton acceptor
Binding site78Mg2+ (UniProtKB | ChEBI)
Binding site79substrate
Binding site161-164substrate
Binding site184substrate
Binding site189-190substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      bhn_I2211

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MB2003
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Butyrivibrio

Accessions

  • Primary accession
    A0A1D9P4H0

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    206
  • Mass (Da)
    22,798
  • Last updated
    2017-02-15 v1
  • Checksum
    B5352A479EC75DB2
MRIVFATGNKNKMIEIREILGDLGVEILSMKEAGVEGDVEENGTTFAENSLIKSKAVYEELKAKEPEKAAETIVLADDSGLEIDYLNKEPGIYSARYMGKDTSYTEKNNNLIERLNGVPDEKRTARFVCAISAFLPDGSSLSTLGTIEGRIGYEIAGENGFGYDPIFYLPEYGKTSAEISPEEKNAISHRGKALREMEKLLREKIS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP017831
EMBL· GenBank· DDBJ
AOZ97244.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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