A0A1D8RF28 · A0A1D8RF28_CTEID

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Pathway

Lipid metabolism; prostaglandin biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site109substrate
Active site189Proton acceptor
Active site367For cyclooxygenase activity
Binding site370Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functiondioxygenase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functionperoxidase activity
Molecular Functionprostaglandin-endoperoxide synthase activity
Biological Processprostaglandin biosynthetic process
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin G/H synthase 2
  • EC number
  • Alternative names
    • Cyclooxygenase-2
    • PHS II
    • Prostaglandin H2 synthase 2
    • Prostaglandin-endoperoxide synthase 2

Gene names

    • Name
      COX-2a

Organism names

Accessions

  • Primary accession
    A0A1D8RF28

Subcellular Location

Endoplasmic reticulum membrane
; Peripheral membrane protein
Membrane
; Peripheral membrane protein
Microsome membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_500911160921-601Prostaglandin G/H synthase 2

PTM databases

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain20-58EGF-like
Region578-601Disordered

Sequence similarities

Belongs to the prostaglandin G/H synthase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    601
  • Mass (Da)
    69,043
  • Last updated
    2017-01-18 v1
  • Checksum
    0E86514244C217CA
MNKLVCLVLLSSFWIFPGEGYDPCCAQPCQNQGVCLSKGADAYECDCTRTGYYGENCTTPELLTRIRSTLKPQANIVHYVLTHYKWIWDIINNISFLRDGIMRYVLTSRSHLVDSPPTYNADYNYKSWEAYSNLSYYTRTLAPLPQNCPTLELPNAKQVVEKVLLRKQFIPDPQRSSLMFAFFAQHFTHQFFKSDFKKGPAFTKALGHGVDLGHIYGETLERQHKLRQFKDGKLKYQVVDGEVYPPLVKDVQVEMHYPPHVPEQHKFAVGHEAFGLVPGLMMYATIWLREHNRVCDIMKQEHPDWDDERIFQTTRLILIGETIKIVIEDYVQHLSGYNFKLKFDPELLFNQRFQYQNRIAAEFNTLYHWHPLMPDNFQIQDQVYGYHQFVFNNSIVTEHGIRNMVESFTKQMAGRVSGGRNLPASVQGVAVNALEHSRQMRYQSFNAYRKRFNMKPYSSFEEMTGDKELADELKKLYGHIDAVELYPGLLVEKPRPNAVFGETMVEMGAPYSLKGLMGNAICSPEYWMPSTFGGKVGFDIVNTASLKKLVCSNINGPCPMVSFQVPDVKVQSLENMNSSSVHSTQNNVNPTVVLNERSSEL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue601

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU878099
EMBL· GenBank· DDBJ
AOW71509.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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