A0A1D8PJX3 · RIP1_CANAL

Function

function

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:34525326, PubMed:36923588).
The complex plays an important role in the uptake of multiple carbon sources present in different host niches (PubMed:36923588).

Catalytic activity

Cofactor

[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 1 [2Fe-2S] cluster per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site156[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site158[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site175[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site178[2Fe-2S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex III
Cellular Componentplasma membrane
Molecular Function2 iron, 2 sulfur cluster binding
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processmitochondrial electron transport, ubiquinol to cytochrome c

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b-c1 complex subunit Rieske, mitochondrial
  • EC number
  • Alternative names
    • Complex III subunit 7

Gene names

    • Name
      RIP1
    • Ordered locus names
      CAALFM_C304430WA, orf19.13314

Organism names

Accessions

  • Primary accession
    A0A1D8PJX3

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain30-47Mitochondrial matrix
Transmembrane48-77Helical
Topological domain78-213Mitochondrial intermembrane

Keywords

Phenotypes & Variants

Disruption phenotype

Leads to hypersensitivity to azole treatment and sharply curtails fungal growth in the presence of macrophages (PubMed:27524297).
Leads to decreased vegetative growth on several carbon sources including maltose, citrate and acetate (PubMed:36923588).

PTM/Processing

Features

Showing features for transit peptide, chain, disulfide bond.

TypeIDPosition(s)Description
Transit peptide1-29Mitochondrion
ChainPRO_000045922730-213Cytochrome b-c1 complex subunit Rieske, mitochondrial
Disulfide bond161↔177

Keywords

Expression

Induction

Expression is induced in high iron conditions (PubMed:15387822).
Expression is repressed in alkaline conditions, by niric oxide and during spider biofilm formation (PubMed:15554973, PubMed:16030247, PubMed:22265407).
Expression is also repressed by HAP43 (PubMed:21592964).

Interaction

Subunit

Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III2IV and III2IV2).

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain116-211Rieske

Sequence similarities

Belongs to the Rieske iron-sulfur protein family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    213
  • Mass (Da)
    23,207
  • Last updated
    2017-01-18 v1
  • Checksum
    9D05599669F41ECB
MSSLAFRTLRNGLGLKSSVRALSTTTTTLSNYQQPDYSSYLNNKSGQGSRNFTYFMVGSMGLLSAAGAKSTVEAFLSSFAASADVLAMAKVEVKLGAIPEGKNVIIKWQGKPVFIRHRTADEIEEANQVDIKTLRDPQNDADRVKKPEWLIMLGICTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEIPEYDFTDDETLLVG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP017625
EMBL· GenBank· DDBJ
AOW28461.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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