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A0A1D8PC43 · MVD1_CANAL

Function

function

Diphosphomevalonate decarboxylase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:12073030).
MVD1 converts diphosphomevalonate into isopentenyl diphosphate (PubMed:12073030).
The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable)

Catalytic activity

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site17-20(R)-5-diphosphomevalonate (UniProtKB | ChEBI)
Binding site72(R)-5-diphosphomevalonate (UniProtKB | ChEBI)
Binding site150-155(R)-5-diphosphomevalonate (UniProtKB | ChEBI)
Binding site206(R)-5-diphosphomevalonate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functiondiphosphomevalonate decarboxylase activity
Biological Processisopentenyl diphosphate biosynthetic process, mevalonate pathway
Biological Processsterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diphosphomevalonate decarboxylase
  • EC number
  • Alternative names
    • Mevalonate pyrophosphate decarboxylase
      (MPD
      )
    • Mevalonate-5-diphosphate decarboxylase
      (MDD
      ; MDDase
      )

Gene names

    • Name
      MVD
    • Synonyms
      MVD1
    • ORF names
      CAALFM_C100070WA
    • Ordered locus names
      orf19.6105

Organism names

Accessions

  • Primary accession
    A0A1D8PC43

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004541681-362Diphosphomevalonate decarboxylase

Expression

Induction

Expression is high in media supplemented with glucose, moderate in acetate, galactose and low in maltose medium (PubMed:12073030).
Expression is higher in the yeast phase than in the hyphal phase of growth as well as higher in the exponential than in the stationary phase (PubMed:12073030).
Expression is affected by antifungals (PubMed:15917516).
Expression is repressed during biofilm formation (PubMed:19527170, PubMed:22265407).

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    362
  • Mass (Da)
    39,544
  • Last updated
    2017-01-18 v1
  • MD5 Checksum
    1DC0A407A26CB1687F646C8655AB1CBA
MYSASVTAPVNIATLKYWGKRDKSLNLPTNSSISVTLSQDDLRTLTTASASESFEKDQLWLNGKLESLDTPRTQACLADLRKLRASIEQSPDTPKLSQMKLHIVSENNFPTAAGLASSAAGFAALVSAIAKLYELPQDMSELSKIARKGSGSACRSLFGGFVAWEMGTLPDGQDSKAVEIAPLEHWPSLRAVILVVSDDKKDTPSTTGMQSTVATSDLFAHRIAEVVPQRFEAMKKAILDKDFPKFAELTMKDSNSFHAVCLDSYPPIFYLNDTSKKIIKMVETINQQEVVAAYTFDAGPNAVIYYDEANQDKVLSLLYKHFGHVPGWKTHYTAETPVAGVSRIIQTSIGPGPQETSESLTK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP017623
EMBL· GenBank· DDBJ
AOW25709.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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